Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries

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Abstract

The spread of the HIV-1 circular recombinant CRF02-AG in countries of the former Soviet Union (Commonwealth of Independent States, CIS ) was studied using partial and full-genome sequences. The full-genome sequence of the CRF02-AG recombinant circulating in Russia was obtained for the first time. A global phylogenetic tree of CRF02-AG full-genome sequences was constructed. Three distinct groups of the sequences were detected as clustered by the geographical location (CIS, South Korea, and France), which is indicative of the single-virus introduction in each of the regions mentioned above. The CIS cluster exhibiting minimum genetic diversity was, therefore, relatively young. The phylogenetic analysis of the env gene sequences within the CIS cluster made it possible to clearly discriminate three branches: two of Russian and one of Uzbek origin. The low genetic diversity within the two Russian subclusters provides evidence of at least two recent independent introductions of the CRF02-AG recombinant from Central Asia into Russia.

About the authors

F. F. Moskaleychik

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: fedor.mosckaleychick@gmail.com

Fedor Moskaleychik, MD,PhD

123098, Moscow

Russian Federation

V. Yu. Laga

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru
123098, Moscow Russian Federation

E. Delgado

Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda

Email: fake@neicon.ru
Madrid Spain

Y. Vega

Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda

Email: fake@neicon.ru
Madrid Spain

A. Fernandez-Garcia

Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda

Email: fake@neicon.ru
Madrid Spain

L. Perez-Alvarez

Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda

Email: fake@neicon.ru
Madrid Spain

G. V. Kornilaeva

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru
123098, Moscow Russian Federation

A. Yu. Pronin

AIDS Center of Moscow Region

Email: fake@neicon.ru
129110, Moscow Russian Federation

Yu. V. Zhernov

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru
123098, Moscow Russian Federation

M. M. Thomson

Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda

Email: fake@neicon.ru
Madrid Spain

M. R. Bobkova

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru
123098, Moscow Russian Federation

E. V. Karamov

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru
123098, Moscow Russian Federation

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Copyright (c) 2015 Moskaleychik F.F., Laga V.Y., Delgado E., Vega Y., Fernandez-Garcia A., Perez-Alvarez L., Kornilaeva G.V., Pronin A.Y., Zhernov Y.V., Thomson M.M., Bobkova M.R., Karamov E.V.

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