Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries

F. F. Moskaleychik; Москалейчик Ф. Ф.; V. Yu. Laga; Лага В. Ю.; E. Delgado; Дельгадо Е.; Y. Vega; Вега И.; A. Fernandez-Garcia; Фернандес-Гарсия А.; L. Perez-Alvarez; Перес-Альварес Л.; G. V. Kornilaeva; Корнилаева Г. В.; A. Yu. Pronin; Пронин А. Ю.; Yu. V. Zhernov; Жернов Ю. В.; M. M. Thomson; Томсон М. М.; M. R. Bobkova; Бобкова М. Р.; E. V. Karamov; Карамов Э. В.

Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries

Authors: Moskaleychik F.F.¹, Laga V.Y.¹, Delgado E.², Vega Y.², Fernandez-Garcia A.², Perez-Alvarez L.², Kornilaeva G.V.¹, Pronin A.Y.³, Zhernov Y.V.¹, Thomson M.M.², Bobkova M.R.¹, Karamov E.V.¹
Affiliations:
1. “The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation
2. Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda
3. AIDS Center of Moscow Region
Issue: Vol 60, No 6 (2015)
Pages: 14-19
Section: ORIGINAL RESEARCH
URL: https://virusjour.crie.ru/jour/article/view/361
ID: 361

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Abstract

The spread of the HIV-1 circular recombinant CRF02-AG in countries of the former Soviet Union (Commonwealth of Independent States, CIS ) was studied using partial and full-genome sequences. The full-genome sequence of the CRF02-AG recombinant circulating in Russia was obtained for the first time. A global phylogenetic tree of CRF02-AG full-genome sequences was constructed. Three distinct groups of the sequences were detected as clustered by the geographical location (CIS, South Korea, and France), which is indicative of the single-virus introduction in each of the regions mentioned above. The CIS cluster exhibiting minimum genetic diversity was, therefore, relatively young. The phylogenetic analysis of the env gene sequences within the CIS cluster made it possible to clearly discriminate three branches: two of Russian and one of Uzbek origin. The low genetic diversity within the two Russian subclusters provides evidence of at least two recent independent introductions of the CRF02-AG recombinant from Central Asia into Russia.

Keywords

HIV, subtype, circular recombinant form, molecular epidemiology, phylogenetic tree

About the authors

F. F. Moskaleychik

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: fedor.mosckaleychick@gmail.com

Fedor Moskaleychik, MD,PhD

123098, Moscow

Russian Federation

References

Karamov E.V., Yaroslavtseva N.G., Shchelkanov M.Y., Martovitski D., Lukashov V., Kozlov A.P. et al. Antigenic and genetic relations between different HIV-1 subtypes in Russia. Immunol. Infect. Dis. 1996; 6: 15–24.
Lukashov V.V., Cornelissen M.T., Goudsmit J., Papuashvilli M.N., Rytik P.G., Khaitov R.M. et al. Simultaneous introduction of distinct HIV-1 subtypes into different risk groups in Russia, Byelorussia and Lithuania. AIDS. 1995; 9 (5): 435–9.
Hamers F.F. HIV infection in Ukraine (1987–96). Rev. Epidemiol. Sante Publique. 2000; 48 (Suppl. 1): 1S3–15.
Novitsky V.A., Montano M.A., Essex M. Molecular epidemiology of an HIV-1 subtype A subcluster among injection drug users in the Southern Ukraine. AIDS Res. Hum. Retroviruses. 1998; 14 (12): 1079–85.
Bobkov A., Cheingsong-Popov R., Selimova L., Ladnaya N., Kazennova E., Kravchenko A. et al. An HIV type 1 epidemic among injecting drug users in the former Soviet Union caused by a homogeneous subtype A strain. AIDS Res. Hum. Retroviruses. 1997; 13 (14): 1195–201.
Lukashov V.V., Karamov E.V., Eremin V.F., Titov L.P., Goudsmit J. Extreme founder effect in an HIV type 1 subtype A epidemic among drug users in Svetlogorsk, Belarus. AIDS Res. Hum. Retroviruses. 1998; 14 (14): 1299–303.
Fernandez-Garcia A., Revilla A., Vazquez-de Parga E., Vinogradova A., Rakhmanova A., Karamov E. et al. The analysis of near full-length genome sequences of HIV type 1 subtype A viruses from Russia supports the monophyly of major intrasubtype clusters. AIDS Res. Hum. Retroviruses. 2012; 28 (10): 1340–3.
Nabatov A.A., Kravchenko O.N., Lyulchuk M.G., Shcherbinskaya A.M., Lukashov V.V. Simultaneous introduction of HIV type 1 subtype A and B viruses into injecting drug users in southern Ukraine at the beginning of the epidemic in the former Soviet Union. AIDS Res. Hum. Retroviruses. 2002; 18 (12): 891–5.
Thomson M.M., de Parga E.V., Vinogradova A., Sierra M., Yakovlev A., Rakhmanova A. et al. New insights into the origin of the HIV type 1 subtype A epidemic in former Soviet Union’s countries derived from sequence analyses of preepidemically transmitted viruses. AIDS Res. Hum. Retroviruses. 2007; 23 (12): 1599–604.
Казеннова Е.В., Васильев А.В., Лаповок И.А., Гришечкин А.Е., Лага В.Ю., Саламов Г.Г. и др. Генетические варианты ВИЧ-1 в азиатской части России. Вопросы вирусологии. 2013; 58 (4): 28–35.
Liitsola K., Holm K., Bobkov A., Pokrovsky V., Smolskaya T., Leinikki P. et al. An AB recombinant and its parental HIV type 1 strains in the area of the former Soviet Union: low requirements for sequence identity in recombination. UNAIDS Virus Isolation Network. AIDS Res. Hum. Retroviruses. 2000; 16 (11): 1047–53.
Liitsola K., Tashkinova I., Laukkanen T., Korovina G., Smolskaja T., Momot O. et al. HIV-1 genetic subtype A/B recombinant strain causing an explosive epidemic in injecting drug users in Kaliningrad. AIDS. 1998; 12 (14): 1907–19.
Карамов Э.В., Гашникова Н.М., Дроздов И.Г., Онищенко Г.Г. Мониторинг ВИЧ-инфекции в Евразии. Атлас вирусов иммунодефицита человека. Новосибирск: ЦЭРИС; 2009.
Kazennova E., Laga V., Lapovok I., Glushchenko N., Neshumaev D., Vasilyev A. et al. HIV-1 Genetic Variants in the Russian Far East. AIDS Res. Hum. Retroviruses. 2014; 30 (8): 742–52.
Baryshev P.B., Bogachev V.V., Gashnikova N.M. Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia. Arch. Virol. 2012; 157 (12): 2335–41.
Гашникова Н.М., Сафронов П.Ф., Никонорова Ю.В., Унагаева Н.В., Лаптева Т.А. Свойства изолятов CRF02_AG ВИЧ-1, циркулирующих на территории Новосибирской области. Журнал микробиологии, эпидемиологии и иммунобиологии. 2011; 3: 38–43.
Kurbanov F., Kondo M., Tanaka Y., Zalalieva M., Giasova G., Shima T. et al. Human immunodeficiency virus in Uzbekistan: epidemiological and genetic analyses. AIDS Res. Hum. Retroviruses. 2003; 19 (9): 731–8.
Carr J.K., Nadai Y., Eyzaguirre L., Saad M.D., Khakimov M.M.,Yakubov S.K. et al. Outbreak of a West African recombinant of HIV-1 in Tashkent, Uzbekistan. J. Acquir. Immune. Defic. Syndr. 2005; 39 (5): 570–5.
Palm A.A., Esbjornsson J., Mansson F., Kvist A., Isberg P.E., Biague A. et al. Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/ CRF02_AG compared with sub-subtype A3. J. Infect. Dis. 2014; 209 (5): 721–8.

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Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries

Full Text

Abstract

Keywords

About the authors

References

Supplementary files

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