Email this article Evolution ofthe receptor specificity of influenza viruses hemagglutinin in its transfer from duck to pig and man
- Issue: Vol 49, No 3 (2004)
- Pages: 25-31
- Section: Articles
- URL: https://virusjour.crie.ru/jour/article/view/11846
- ID: 11846
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Abstract
The receptor properties of Н1 and H2 influenza viruses (IV), isolated from duck, pig and man were studied by using
the natural and synthetic sialoglycoconjugates. It was shown that viruses, isolated from different hosts, adapt
themselves to the host cell receptors. The IV affinity was increasing to 6'sialy(N-acetyllactosamine) in proportion
as amino acids (in positions 138,190,194 and 225), which are for avian IV, were increasingly replacing. Some of
the porcine viruses display adaptation to the human receptor, i.e. 6'sialy (N-acety llactosamine), however, all tested
porcine influenza viruses, belonging to different evolution branches, acquired even more affinity to sulphated and
fucozyled derivatives of 3'sialy(N-acetyllactosamine) - (Neu5ACa2-3gALpi-4(fUCa1-3)(6-sulfo)GlcNAcp).
the natural and synthetic sialoglycoconjugates. It was shown that viruses, isolated from different hosts, adapt
themselves to the host cell receptors. The IV affinity was increasing to 6'sialy(N-acetyllactosamine) in proportion
as amino acids (in positions 138,190,194 and 225), which are for avian IV, were increasingly replacing. Some of
the porcine viruses display adaptation to the human receptor, i.e. 6'sialy (N-acety llactosamine), however, all tested
porcine influenza viruses, belonging to different evolution branches, acquired even more affinity to sulphated and
fucozyled derivatives of 3'sialy(N-acetyllactosamine) - (Neu5ACa2-3gALpi-4(fUCa1-3)(6-sulfo)GlcNAcp).
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References
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).