Email this article Influence of the immunomodulatory drug stimforte on the humoral immune response in the experimental herpes virus infection
- Authors: Maldov D.G.1, Andronova V.L.2, Balakina A.A.3, Ilyichev A.V.1, Galegov G.A.1
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Affiliations:
- ZAO «SKY LTD»
- «Federal Research Centre of Epidemilogy and Microbiology named after the honorary academician N.F. Gamaleya»
- Institute of Problems of Chemical Physics
- Issue: Vol 61, No 4 (2016)
- Pages: 172-175
- Section: ORIGINAL RESEARCH
- URL: https://virusjour.crie.ru/jour/article/view/74
- DOI: https://doi.org/10.18821/0507-4088-2016-61-4-172-175
- ID: 74
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Abstract
In the study of the immunostimulation preparation Stimforte activity using the model of the experimental herpes virus infection BALB/c, mice has shown that sera from mice treated with the drug on the 4th and 7th day after infection possessed a 3 times greater capability of specifically binding to the culture of HSV-1 (on cells Vero) according to dot blot analysis, as compared with intact infected mice sera obtained at the same time. It was also shown that these sera had a 5 times higher index of neutralization. On the basis of Western blots, it was detected that antibodies from sera of mice treated with Stimforte contacted the glycoproteins gB and gC of HSV-1 significantly better. Thus, Stimforte stimulates one of the strongest modulatory effects on the immune memory and is a promising drug for the treatment of chronic viral diseases.
About the authors
D. G. Maldov
ZAO «SKY LTD»
Author for correspondence.
Email: maldov-dv@yandex.ru
Russian Federation
V. L. Andronova
«Federal Research Centre of Epidemilogy and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
Russian Federation
A. A. Balakina
Institute of Problems of Chemical Physics
Email: noemail@neicon.ru
Russian Federation
A. V. Ilyichev
ZAO «SKY LTD»
Email: noemail@neicon.ru
Russian Federation
G. A. Galegov
ZAO «SKY LTD»
Email: noemail@neicon.ru
Russian Federation
References
- Díaz-Ramón J.L., Dĺaz-Pérez J.L. Skin diseases with high public health impact. Herpes simplex and zoster. Eur. J. Dermatol. 2008; 18 (1): 108-11.
- Pereira F.A. Herpes simplex: evolving concepts. J. Am.Acad. Dermatol. 1996; 35 (4): 503-20.
- Мальдов Д.Г., Чирвон Е.А., Ильичев А.В., Бабаян С.С. Активация препаратом «Стимфорте» моноцитов и макрофагов. Иммунология. 2011; (5): 105-12.
- Мальдов Д.Г., Григорян С.С., Муругин В., Ильичев А.В., Чубарова Г.Д., Бельков А.П. Гликозаминогликаны в составе Стимфорте. Фармация. 2014; (8): 27-31.
- Akbarshahi H., Axelsson J.B., Said K., Malmström A., Fischer H., Andersson R. TLR4 dependent ignalisulphate-induced pancreatic inflammatory response is IRF3-mediated. J. Transl. Med. 2011; 9: 219.
- Kumar S., Iyer S., Bauer H., Coenen M., Bahn R.S. A stimulatory thyrotropin receptor antibody enhances hyaluronic acid synthesis in graves’ orbital fibroblasts: inhibition by an IGF-I receptor blocking antibody. J. Clin. Endocrinol. Metab. 2012; 97 (5): 1681-7.
- Ma L., Qiao H., He C., Yang Q., Cheung C.H., Kanwar J.R. et al. Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer. Invest. New Drugs. 2012; 30 (2): 508-17.
- Scott R.A., Panitch A. Glycosaminoglycans in biomedicine. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2013; 5 (4): 388-98.
- Мальдов Д.Г., Муругин В., Ильичев А.В., Чубарова Г.Д., Иванова Н.Е., Бельков А.П. Гиалуроновая кислота в составе Стимфорте. Фармация. 2013; (4): 40-3.
- Ступина Т.С., Пархоменко И.И., Балалаева И.В., Костюк Г.В., Санина Н.А., Терентьев А. А. Цитотоксические свойства нитрозильного комплекса железа с фенилтиилом. Известия Академии наук. Серия химическая. 2011; (7): 1464-9.
- Grandi P., Wang S., Schuback D., Krasnykh V., Spear M., Curiel D.T. et al. HSV-1 virions engineered for specific binding to cell surface receptors. Mol. Ther. 2004; 9 (3): 419-27.
- Glorioso J., Kees U., Kumel G., Kirchner H., Krammer P.H. Identification of herpes simplex virus type 1 (HSV-1) glycoprotein gC as the immunodominant antigen for HSV-1-specific memory cytotoxic T Iymphocytes. J. Immunol. 1985; 135 (1): 575-82.
- Kishore J., Misra R., Paisal A., Pradeep Y. Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with highrisk pregnancy. J. Infect. Dev. Ctries. 2011; 5 (12): 868-73.
- Stanberry L.R., Cunningham A.L., Mindel A., Scott L.L., Spruance S.L., Aoki F.Y. et al. Prospects for control of herpes simplex virus disease through immunization. Clin. Infect. Dis. 2000; 30 (3): 549-66.
- Ashley R.L., Corey L., Dalessio J., Wilson P., Remington M., Barnum G. et al. Protein-specific cervical antibody responses to primary genital herpes simplex virus type 2 infections. J. Infect. Dis. 1994; 170 (1): 20-6.
- Зуйкова И.Н., Шульженко А.Е., Мальдов Д.Г., Ильичев А.В., Пинегин Б.В. Применение препарата «Стимфорте» в комплексной терапии рецидивирующей герпес-вирусной инфекции. Герпес. 2009; (2): 30-6.
- Погорельская Л.В., Хлопова И.Н., Григорян С.С., Трякина И.П., Рик Н.А., Мальдов Д.Г. Перспективы использования «Стимфорте» при хроническом гепатите В. Эпидемиология и инфекционные болезни. 2013; (5): 15-20.
- Погорельская Л.В., Хлопова И.Н., Григорян С.С., Трякина И.П., Рик Н.А., Мальдов Д.Г. Клинико-иммунологическая и вирусологическая оценка препарата «Стимфорте» при остром гепатите В. Эпидемиология и инфекционные болезни. 2013; (3): 14-8.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).