New approaches to the treatment of the flavivirus infections

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  • Authors: Morozova O.V.1, Isaeva E.I.1, Viazov S.O.2
  • Affiliations:
    1. “The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation
    2. Virology Institute of University Hospital
  • Issue: Vol 60, No 6 (2015)
  • Pages: 5-9
  • Section: REVIEWS
  • URL: https://virusjour.crie.ru/jour/article/view/359
  • ID: 359

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Abstract

Since spontaneous mutagenesis and quasi-species rearrangements of the ma-containing viruses, as well as an absence of both viral and cellular RNA reparation systems, causes resistance to originally effective antiviral drugs, combination therapy with nucleoside and non-nucleoside inhibitors of the viral enzymes in combination with immunomodulators is recommended. The use of specific immunoglobulins does not result in complete elimination of the flaviviruses but rather in possible antibody-dependent enhancement of the flavivirus infection by means of increased penetration of complexes of virions with specific antibodies into cells with receptors for Fc-fragments of immunoglobulins.

About the authors

O. V. Morozova

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: omorozova2010@gmail.com

Olga Morozova, MD,PhD, ScD

123098, Moscow

Russian Federation

E. I. Isaeva

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru
123098, Moscow Russian Federation

S. O. Viazov

Virology Institute of University Hospital

Email: fake@neicon.ru
Essen Germany

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Copyright (c) 2015 Morozova O.V., Isaeva E.I., Viazov S.O.

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