Experimental model of secondary bacterial pneumonia after influenza

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Abstract

In this work, we developed and characterized a mouse model of the secondary bacterial pneumonia after influenza. Specifically, the S. aureus 1986 given intranasally to the mice infected intranasally with the A/California/04/2009 (H1N1 pndm) virus resulted in greater mortality, weight loss, and reduction of mean life time as compared with infection with either pathogen alone. These data were confirmed by the virological and microbiological studies. Both viral and bacterial lung titers were enhanced during coinfections compared with single infections. In addition, preceding influenza infection resulted in a decreased clearance of the virus and S. aureus in lungs of mice. These findings indicate that the influenza virus exacerbates the S. aureus pneumonia and its pathogen factors in mice.

About the authors

I. А. Leneva

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: fake@neicon.ru
Moscow Russian Federation

E. I. Leonova

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: fake@neicon.ru
Moscow Russian Federation

N. R. Маkhmudоvа

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: fake@neicon.ru
Moscow Russian Federation

I. N. Falynskova

I.I. Mechnikov Research Institute of Vaccines and Sera

Author for correspondence.
Email: falynskova@mail.ru

Irina Falynskova, research fellow

Moscow

Russian Federation

I. Т. Fedyakina

D.I. Ivanovsky Institute of Virology «Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: fake@neicon.ru
Moscow Russian Federation

V. V. Zverev

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: fake@neicon.ru
Moscow Russian Federation

N. A. Mikhailova

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: fake@neicon.ru
Moscow Russian Federation

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Copyright (c) 2015 Leneva I.А., Leonova E.I., Маkhmudоvа N.R., Falynskova I.N., Fedyakina I.Т., Zverev V.V., Mikhailova N.A.

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