Molecular epidemiological analysis of HIV-1 in Kazakhstan in 2009-2013

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Abstract

In this study pol gene analysis of 205 HIV-1 samples collected in Kazakhstan in 2009 and 2012-2013 was carried out. CRF02_AG variant is dominating in almaty and actively circulates in East Kazakhstan Province. IDU-A variant is dominating in the rest of Kazakhstan. The data on low prevalence (3%) of HIV drug resistance mutations in native patients were obtained.

About the authors

I. A. Lapovok

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Author for correspondence.
Email: i_lapovok@mail.ru

Ilya Lapovok, MD,PhD

123098, Moscow

Russian Federation

V. Y. Laga

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

E. V. Kazennova

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

A. V. Vasilyev

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

N. V. Dzissyuk

Republican AIDS Center

Email: fake@neicon.ru
050008, Almaty Kazakhstan

A. K. Utegenova

Republican AIDS Center

Email: fake@neicon.ru
050008, Almaty Kazakhstan

A. T. Abishev

Republican AIDS Center

Email: fake@neicon.ru
050008, Almaty Kazakhstan

M. S. Tukeev

Republican AIDS Center

Email: fake@neicon.ru
050008, Almaty Kazakhstan

M. R. Bobkova

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

References

  1. Global report: UNAIDS report on the global AIDS epidemic 2012. Geneva: UNAIDS; 2012.
  2. Ганина Л.Ю. Национальный отчет о выполнении дозорного эпидемиологического надзора в 2009 году. Алматы; 2010.
  3. Тукеев М.С., Елизарьева А.В., Бокажанова А.Т., Петренко И.И., Ганина Л.Ю., Касымбекова С.Ж. Национальный отчет о выполнении Декларации о приверженности делу борьбы с ВИЧ и СПИД. Отчетный период: январь 2010 года – декабрь 2011 года. Алматы; 2012.
  4. Carr J.K., Nadai, Y., Eyzaguirre L., Saad M.D., Khakimov M.M., Yakubov S.K. et al. Outbreak of a West African recombinant of HIV-1 in Tashkent, Uzbekistan. J. Acquir. Immune Defic. Syndr. 2005; 39 (5): 570–5.
  5. Kurbanov F., Kondo M., Tanaka Y., Zalalieva M., Giasova G., Shima T. et al. Human immunodeficiency virus in Uzbekistan: epidemiological and genetic analyses. AIDS Res. Hum. Retroviruses. 2003; 19 (9): 731–8.
  6. Bobkov A.F., Kazennova E.V., Sukhanova A.L., Bobkova M.R., Pokrovsky V.V., Zeman V.V. et al. An HIV type 1 subtype A outbreak among injecting drug users in Kazakhstan. AIDS Res. Hum. Retroviruses. 2004; 20 (10): 1134–6.
  7. Eyzaguirre L.M., Erasilova I.B., Nadai Y., Saad M.D., Kovtunenko N.G., Gomatos P.J. et al. Genetic characterization of HIV-1 strains circulating in Kazakhstan. J. Acquir. Immune Defic. Syndr. 2007; 46 (1): 19–23.
  8. Andersson S., Norrgren H., Dias F., Biberfeld G., Albert J. Molecular characterization of human immunodeficiency virus (HIV)-1 and -2 in individuals from guinea-bissau with single or dual infections: predominance of a distinct HIV-1 subtype A/G recombinant in West Africa. Virology. 1999; 262 (2): 312–20.
  9. Dowling W.E., Kim B., Mason C.J., Wasunna K.M., Alam U., Elson L. et al. Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS. 2002; 16 (13): 1809–20.
  10. Zhang M., Foley B., Schultz A.K., Macke J.P., Bulla I., Stanke M. et al. The role of recombination in the emergence of a complex and dynamic HIV epidemic. Retrovirology. 2010; 7: 25. Avaible at: http://www.retrovirology.com/content/7/1/25
  11. Shahriar R., Rhee, S.Y., Liu T.F., Fessel W.J., Scarsella A., Towner W. et al. Nonpolymorphic human immunodeficiency virus type 1 protease and reverse transcriptase treatment-selected mutations. Antimicrob. Agents Chemother. 2009; 53 (11): 4869–78.
  12. HIV Drug Resistance Database. Avaible at: http://hivdb.stanford.edu.
  13. Manual of QIAamp DNA Blood Mini QIAcube Kit. Avaible at: https://www.qiagen.com/ru/products/catalog/automated-solutions/sample-prep/qiaamp-dna-blood-mini-qiacube-kit
  14. Лага В.Ю., Казеннова Е.В., Васильев А.В., Лаповок И.А., Исмаилова А., Бейшеева Н. Молекулярно-генетическая характеристика вариантов ВИЧ-1, распространенных на территории Киргизии. Вопросы вирусологии. 2012; 57 (5): 26–32.
  15. Tamura K., Peterson D., Peterson N., Stecher G., Nei M., Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 2011; 28 (10): 2731–9.
  16. COntext-based Modeling for Expeditious Typing HIV-1. Avaible at: http://comet.retrovirology.lu/.
  17. HIV Databases. Avaible at: http://www.hiv.lanl.gov/.
  18. Baryshev P.B., Bogachev V.V., Gashnikova N.M. Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia. Arch. Virol. 2012; 157 (12): 2335–41.
  19. Лаповок И.А., Лага В.Ю., Васильев А.В., Саламов Г.Г., Казеннова Е.В., Матковский И.А. и др. Молекулярно-генетический анализ области гена pol, кодирующей интегразу ВИЧ-1, среди пациентов из России и Украины. ВИЧ-инфеккция и иммуносупрессии. 2012; 4 (2): 73–81.

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Copyright (c) 2015 Lapovok I.A., Laga V.Y., Kazennova E.V., Vasilyev A.V., Dzissyuk N.V., Utegenova A.K., Abishev A.T., Tukeev M.S., Bobkova M.R.

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