Molecular genetic characteristics of the virus isolated from patients with human acute encephalomyelitis and multiple sclerosis

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Abstract

The study of the antigenic and molecular genetic structure of human acute encephalomyelitis virus (HAEV) showed a high similarity of the HAEV N gene with the homologous gene of the fixed rabies virus strain. The results of the nucleotide sequence analysis indicate that HAEV belongs to the lyssavirus genotype 1. The N gene sequence is the closest to those of the ERA-CB20-M and RV-97 strains of the rabies virus. The need for further research into the role of the human acute encephalomyelitis virus in human pathology stems from past surveys that revealed the presence of the VNAs against this virus in 6 per cent of the blood received from donors in the USA and in each third among the patients with multiple sclerosis in the former USSR.

About the authors

I. F. Barinsky

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

T. V. Grebennikova

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

S. V. Alkhovsky

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

K. S. Kochergin-Nikitsky

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

O. V. Sergeyev

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Author for correspondence.
Email: osergeyev123@gmail.com

Oleg Sergeev, MD, PhD

123098, Moscow

Russian Federation

S. V. Gribencha

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

S. A. Raev

The D.I. Ivanovsky Institute of Virology Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

References

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  2. Грибенча С.В., Козлов А.Ю., Костина Л.В., Елаков А.Л., Лосич М.А., Цибезов В.В. и др. Получение моноклональных антител к нуклеопротеину вируса бешенства. Вопросы вирусологии. 2013; 58(5): 38–43.
  3. Грибенча С.В., Львов Д.К. Бешенство. В кн.: Львов Д.К., ред. Вирусы и вирусные заболевания человека и животных. М.: Медицина; 2013: 811.
  4. Delmas O., Holmes E.C., Talbi C., Larrous F., Dacheux L., Bouchier C., Bourhy H. Genomic diversity and evolution of the lyssaviruses. PLoS One. 2008; 3(4): e2057.

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Copyright (c) 2015 Barinsky I.F., Grebennikova T.V., Alkhovsky S.V., Kochergin-Nikitsky K.S., Sergeyev O.V., Gribencha S.V., Raev S.A.

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