Genetic diversity of viruses of Chenuda virus species (Orbivirus, Reoviridae) circulating in Central Asia

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Abstract

Chenuda virus (CNUV) (Orbivirus, Reoviridae) is the only known orbivirus associated with argas (Argasidae) ticks. Scientific study of this group is necessary for understanding of Orbivirus genus evolution patterns. We conducted a comparative analysis of full genomes of five different viruses of Chenuda virus species, including Baku virus strains (BAKV) circulating in a rather limited area in the Central Asia and Transcaucasia. It was shown that VP4(OC1) and VP6(Hel) proteins variability greatly exceeds the variability of other proteins. The divergence between CNUV and BAKV in this proteins is about 50%. Even in closely related strains isolated from the same geographical region, the conservative genes of which are 90-95% identical, the VP4(OC1) and VP6(Hel) divergence reaches values that would usually be indicative of different serotypes (74.1-82.2%).

About the authors

A. A. Eremyan

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

D. K. Lvov

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

A. M. Shchetinin

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

P. G. Deryabin

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

V. A. Aristova

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

A. K. Gitelman

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

A. G. Botikov

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

S. V. Alkhovsky

Federal State Budgetary Institution «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: salkh@ya.ru
Russian Federation

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Copyright (c) 2017 Eremyan A.A., Lvov D.K., Shchetinin A.M., Deryabin P.G., Aristova V.A., Gitelman A.K., Botikov A.G., Alkhovsky S.V.

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