Severe fever with thrombocytopenia syndrome: the disease, caused by the novel phlebovirus

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Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a new virus (SFTS virus) reported to be endemic to central and northeastern parts of China. SFTS virus, which is classified into the genus Phlebovirus (the Bunyaviridae family), is suspected to be a tick-borne virus owing to evidence in two species of ticks: Haemaphysalis longicornis and Rhipicephalus microplus. SFTS virus is detected among many species of domestic animals in China. The clinical symptoms of SFTS include fever, thrombocytopenia, leucocytopenia, gastrointestinal symptoms, neural symptoms, bleeding tendency. The fatality rate of SFTS is 6-30%. Person-to-person transmission of SFTS virus is possible through blood contact. Clinical and epidemiological studies of SFTS, the cases of SFTS outside China, person-to-person transmission of SFTS virus, evolutionary and molecular analysis of the emergent SFTS virus, and risk assessment of human infection with a novel phlebovirus are considered in this review.

About the authors

T. E. Sizikova

48th Central Scientific Research Institute

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

V. N. Lebedev

48th Central Scientific Research Institute

Email: noemail@neicon.ru
Russian Federation

V. B. Pantukhov

48th Central Scientific Research Institute

Email: noemail@neicon.ru
Russian Federation

S. V. Borisevich

48th Central Scientific Research Institute

Email: 48cnii@mil.ru
Russian Federation

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Copyright (c) 2017 Sizikova T.E., Lebedev V.N., Pantukhov V.B., Borisevich S.V.

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