Characterization of vaccine polioviruses isolated in the closed pediatric collective bodies (children's homes)


Cite item

Full Text

Abstract

Examination of 281 healthy vaccinees from 6 children's homes could isolate 37 vaccine polioviruses. The detection rate for polioviruses in the children's homes, in which there were children born to HIV-positive mothers, was significantly higher than that in other children's homes. These children's homes showed the longest poliovirus excretion after vaccination. The RFLP analysis showed that 40% of the strains being examined were intertypic recombinant strains. The sequence analysis demonstrated that about 30% of the strains under study had a small number of nucleotide substitutions in the VP3-VP1 genomic region. The study revealed a correlation between the dynamics of poliovirus excretion after oral vaccination and the kinetics of formation of recombinant poliovirus strains.

References

  1. Иванова О. Е., Романенкова Н. И., Еремеева Т. П. и др. Риск развития случаев острого вялого паралича и вакциноассоциированного полиомиелита в закрытых детских коллективах - домах ребенка и детских лечебных стационарах // Эпид. и вакцинопрофилактика. - 2005. - № 1. - C. 14-18.
  2. Проблемы ликвидации полиомиелита / Онищенко Г. Г., Дроздов С. Г., Лялина Л. В. и др. - СПб., 2008.
  3. Balanant J., Guillot S., Candrea A. et al. The natural genomic variability of poliovirus analyzed by a restriction fragment length polymorphism assay // Virology. - 1991. - Vol. 184. - P. 645-654.
  4. Cammack N., Phillips A., Dunn G. et al. Intertypic genomic rearrangements of poliovirus strains in vaccinees // Virology. - 1988. - Vol. 67. - P. 507-514.
  5. Cherkasova E. A., Yakovenko M. L., Rezapkin G. V. et al. Spread of vaccine-derived poliovirus from a paralytic case in an immunodeficient child: an insight into the natural evolution of oral polio vaccine // J. Virol. -2005. - Vol. 79. - P. 1062- 1070.
  6. Cuervo N., Guillot S., Romanenkova N. et al. Genomic features of intertypic recombinant Sabin strains excreted by primary vaccines // J. Virol. - 2001. - Vol. 75. - P. 5740-5751.
  7. Friedrich F., Da-Silva E. F., Schatzmayr H. G. Type 2 poliovirus recombinants isolated from vaccine-associated cases and from healthy contacts in Brazil // Acta Virol. - 1996. - Vol. 40. - P. 27-33.
  8. Furione M., Guillot S., Otelea D. et al. Polioviruses with natural recombinant genomes isolated from vaccine-associated paralytic poliomyelitis // Virology. - 1993. - Vol. 196. - P. 199- 208.
  9. Gavrilin G. V., Cherkasova L. A., Lipskaya G. Y. et al. Evolution of circulating wild poliovirus and of vaccine-derived poliovirus in an immunodeficient patient: a unifying model // J. Virol. - 2000. - Vol. 74. - P. 7381-7390.
  10. Guillot S., Caro V., Cuervo N. et al. Natural genetic exchanges between vaccine and wild poliovirus strains in humans // J. Virol. -2000. - Vol. 74. - P. 8434-8443.
  11. Kew O. M., Sutter R. W., Nottay B. K. et al. Prolonged replication of a type 1 vaccine-derived poliovirus in an immunodeficient patient // J. Clin. Microbiol. - 1998. - Vol. 36. - P. 2893- 2899.
  12. Kew O. M., Morris-Glasgow V., Landaverde M. et al. Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus // Science. - 2002. - Vol. 296. - P. 356-359.
  13. Lipskaya G. Y., Muzychenko A. R., Kutitova O. K. et al. Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine-associated polio cases // J. Med. Virol. - 1991. - Vol. 35. - P. 290-296.
  14. Paralytic poliomyelitis in Madagascar, 2002 // Wkly Epidemiol. Rec. - 2002. - Vol. 77, N 29. - P. 241.
  15. Romanenkova N. I., Guillot S., Rozaeva N. R. et al. Use of a multiple restriction fragment length polymorphism method for detecting vaccine-derived polioviruses in clinical samples // J. Clin. Microbiol. -2006. - Vol. 44, N 11. - P. 4077-4084.
  16. Shimizu H., Thorley B., Paladin F. J. et al. Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001 // J. Virol. - 2004. - Vol. 78. - P. 13512-13521.
  17. Thompson J. D., Higgins D. G., Gibson T. J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice // Nucl. Acids Res. - 1994. - Vol. 22. - P. 4673-4680.
  18. Van der Avoort H. G., Hull B. P., Hovi T. et al. Comparative study of five methods for intratypic differentiation of polioviruses // J. Clin. Microbiol. -1995. - Vol. 33. - P. 2562- 2566.
  19. World Health Organization. 2004. Polio laboratory manual. WHO/IVB/04.10. - Geneva, 2004.
  20. Yang C. F., De L., Holloway B. P. et al. Detection and identification of vaccine-related polioviruses by the polymerase chain reaction // Virus Res. - 1991. - Vol. 20. - P. 159-179.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2010 Romanenkova N.I., Bichurina M.A., Rozaeva N.R., Romanenkova N.I., Bichurina M.A., Rozaeva N.R.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-77676 от 29.01.2020.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies