CD4+ and CD8+ T-lymphocyte counts in human immunodeficiency virus type 1 subtype A-infected patients carrying mutations V77I in protease and/or A62V in reverse transcriptase


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Abstract

The peripheral blood counts of CD4+, CD8+, and CD4/CD8 in human immunodeficiency virus type 1 subtype A-infected patients were comparatively analyzed with the data of a genetic study of the pol gene. Thirty peripheral blood samples from antiretroviral-naїve patients with grade 3 (sublinical) HIV infection were analyzed. According to the presence or absence of mutations V77I in protease and/or A62V in reverse transcriptase, the patients were divided into 2 study groups. The genetic analysis of the groups indicated that 19.5% of the study samples had no mutations; 75% contained one or both mutations, of them 36% contained both mutations. Immunological study showed that the median CD4+, CD8+, and CD4/CD8 in the patients infected with virus variants containing mutations V77I and/or A62V were increased by 25, 20, and 16%, respectively. The findings suggest that these mutations may be associated with an immune response in HIV-infected patients.

References

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Copyright (c) 2010 Selimova L.M., Serebrovskaya L.V., Ivanova L.A., Nosik D.N., Selimova L.M., Serebrovskaya L.V., Ivanova L.A., Nosik D.N.

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