GBV-C infection in HIV-infected patients in the Russian Federation


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Abstract

The spread and genotypical variability of GBV-C virus were determined among the HIV-positive patients in the Russian Federation. More than a fourth (26.2%) of the HIV-infected patients were shown to have GBV-C coinfection; all virus isolates belonged to genotype 2 with a predominance of subtype 2a. Analysis of the impact of GBV-C coinfection on HIV burden and CD4 lymphocyte levels showed no significant impact on these basic characteristics of HIV infection. However, coinfection with GBV-C and HIV was associated with the higher frequency of undetectably low ( < 400 copies/ml) of HIV burden, which enables GBV-C infection to be regarded as a potentially favorable factor in HIV infection.

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Copyright (c) 2010 Dmitriev P.N., Tsykina M.N., Moiseeva A.V., Serkov I.L., Pronin A.Y., Popova O.E., Isaeva O.V., Kyuregyan K.K., Mikhailov M.I.

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