Strain differences related with Ebola virus reproduction in peritoneal macrophages and in aorta explants of guinea pigs


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Abstract

Reproduction of the Ebola strains (ES) virus causing lethality in guinea pigs as well as in peritoneal macrophages and aorta explants of animals was investigated in vitro and in vivo; besides, production of interferon-y (IFN-y) and of tumor necrosis factor-a (TNF-a) by macrophages and endotheliocytes of guinea pigs was also studied. The interplay "macrophage - ES" by the example of 2 models of susceptibility to ES demonstrates that the ES lethality is not unambiguously related only with a level of virus reproduction in macrophages. The interplay "endotheliocyte - ES" is indicative of that the ES lethality is inversely dependent on a level of production of the IFN-y and of TNF-a by endotheliocytes. In general, the Eboly fever lethality is not conditioned only by the ability or inability of ES to reproduce in macrophages and endotheliocytes; it also depends on a variety of pathogenetic factors, one of which could be the cytotoxic action of immune complexes shaping in the process of infection progression.

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