The study of the humoral immunity to the virus of poliomyelitis among migrant workers in the Russian Federation

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Abstract

At the final stage of the polio eradication, the group of people who could potentially be a source of reintroduction of the wild poliovirus (PV) in the community has a particular importance. Therefore, the goal of the study was to assess risk assessment of maintenance of circulation of the wild PV among migrant workers from Tajikistan based on determining the level of the humoral immunity to PV. We tested 470 serum samples collected from the healthy migrants from Tajikistan in Moscow and Moscow region during the polio outbreak in Tajikistan in 2010. The average age of the donors was 16.7 ± 0.8 years. Children from 0.5 to 14 years (5.6 ± 0.9 years) amounted up to 18.9%; adults under 28 years (20.9 ± 0.3 years), to 49.8%; the group of persons whose age was unknown, 31.3%. Information about previous vaccination against polio was available for 78.7% of children. The level of the neutralizing antibodies (ntAB) to the vaccine PV serotypes 1, 2, and 3 and wild PV type 1 was defined in the microneutralization test in Hep-2 cells. The level of IgM and IgG antibodies to the wild PV was determined in ELISA. The relative amount of children without ntAB to PV type 1, 2, 3, and all three serotypes (8%, 10%, 29%, and 2%, respectively) exceeded the relative amount of such children among the citizens of Russia. The relative amount of the migrant adults without antibodies to PV type 1, 2, 3 and to all three serotypes (35%, 27%, 66%, and 15%, respectively) was significantly higher than the relative amount of persons in the same age group from Russia. Comparison of the antibody levels to vaccine and wild PV type 1 and the ratio of IgM and IgG levels indicated a recent contact with the wild PV type 1. Suboptimal (< 90%) level of the herd immunity to PV could promote the maintenance of PV circulation in the studied group. An elaborate program of vaccinal measures should be developed and implemented with respect to this group.

About the authors

D. A. Sychev

M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides

Email: fake@neicon.ru
Moscow Russian Federation

O. Yu. Baykova

M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides

Email: fake@neicon.ru
Moscow Russian Federation

A. P. Ivanov

Federal State Unitary Enterprise for Manufacture of Bacterial and Viral Preparations, M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides

Email: fake@neicon.ru
Moscow Russian Federation

T. P. Eremeeva

M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides

Email: fake@neicon.ru
Moscow Russian Federation

O. E. Ivanova

M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides; Federal State Unitary Enterprise for Manufacture of Bacterial and Viral Preparations, M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides

Author for correspondence.
Email: poliom@aha.ru

Ol’ga Ivanova, MD, PhD, DSc

Moscow

Russian Federation

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Copyright (c) 2015 Sychev D.A., Baykova O.Y., Ivanov A.P., Eremeeva T.P., Ivanova O.E.

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