Cytokines during the human immunodeficiency virus infection type 1(HIV-1)

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Abstract

In this work the proinflammatory (IL-1β, IFN-γ, TNF-α, IL-2) and anti-inflammatory (IL-4, IL-10) plasma cytokine levels were evaluated in HIV-infected patients with or without antiretroviral treatment (ART). IFN-γ was detected in 94% samples with and without art, TNF-α in 88% and il-2 in 38% samples without ART, as well as in 12% and 30% samples with ART, respectively. Positive correlation was detected between viral RNA and IFN-γ levels (rs = 0.13) and negative correlation (rs = –0.242) in the patients without or with ART. Cosecretion of three cytokines (IFN-γ, TNF-α, IL-2) was detected in 31% samples and two cytokines (IFN-γ, TNF-α) in 35% samples of persons without ART. Cosecretion of three cytokines (IFN-γ, TNF-α, IL-2) was detected in 20% samples with ART; cosecretion of IFN-γ and IL-2 was detected in 10% samples. The higher percentage of the proinflammatory cytokines with cosecretion was detected in plasma HIV-infected patients without ART in the course of 6 and more years, which suggests that their immune system is able to provide disease control.

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About the authors

L. M. Selimova

D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Author for correspondence.
Email: lselim@mail.ru

Ludmila Selimova, MD, PhD, ScD

123098, Moscow

Russian Federation

L. B. Kalnina

D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

L. V. Serebrovskaya

Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: fake@neicon.ru
111123, Moscow Russian Federation

L. A. Ivanova

Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: fake@neicon.ru
111123, Moscow Russian Federation

A. N. Gulyaeva

Hematology Research Center, Ministry of Health of the Russian Federation

Email: fake@neicon.ru
125167, Moscow Russian Federation

D. N. Nosik

D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”

Email: fake@neicon.ru
123098, Moscow Russian Federation

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Copyright (c) 2016 Selimova L.M., Kalnina L.B., Serebrovskaya L.V., Ivanova L.A., Gulyaeva A.N., Nosik D.N.

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