THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B

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Abstract

Chronic hepatitis B is caused by a persistent form of hepatitis B virus, covalently closed circular DNA (cccDNA). Stability of cccDNA is associated with intracellular localization of cccDNA and formation of minichromosome, regulated by epigenetic mechanisms. One of the key mechanisms in epigenetics is methylation of DNA on CpG islands. Expression levels of DNA-methyltransferases (DNMTs) in chronic hepatitis B patients were shown to be upregulated. Nevertheless, the role of DNMTs in the life cycle of HBV and their effects on the cell remain elusive. In this review, we discuss latest achievements on the role of DNMTs in chronic hepatitis B and HBV in vitro models.

About the authors

D. S. Kostyushev

Central Research Institute of Epidemiology

Author for correspondence.
Email: dk@rcvh.ru
Russian Federation

A. P. Zueva

Central Research Institute of Epidemiology; M.V. Lomonosov Moscow State University

Email: noemail@neicon.ru
Russian Federation

S. A. Brezgin

Central Research Institute of Epidemiology; I.M. Sechenov First State Medical University

Email: noemail@neicon.ru
Russian Federation

A. D. Lipatnikov

Central Research Institute of Epidemiology; D.I. Mendeleev University of Chemical Technology of Russia

Email: noemail@neicon.ru
Russian Federation

E. V. Volchkova

I.M. Sechenov First State Medical University

Email: noemail@neicon.ru
Russian Federation

V. V. Maleyev

Central Research Institute of Epidemiology

Email: noemail@neicon.ru
Russian Federation

V. P. Chulanov

Central Research Institute of Epidemiology; I.M. Sechenov First State Medical University

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2018 Kostyushev D.S., Zueva A.P., Brezgin S.A., Lipatnikov A.D., Volchkova E.V., Maleyev V.V., Chulanov V.P.

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