THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B

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Abstract

Chronic hepatitis B is caused by a persistent form of hepatitis B virus, covalently closed circular DNA (cccDNA). Stability of cccDNA is associated with intracellular localization of cccDNA and formation of minichromosome, regulated by epigenetic mechanisms. One of the key mechanisms in epigenetics is methylation of DNA on CpG islands. Expression levels of DNA-methyltransferases (DNMTs) in chronic hepatitis B patients were shown to be upregulated. Nevertheless, the role of DNMTs in the life cycle of HBV and their effects on the cell remain elusive. In this review, we discuss latest achievements on the role of DNMTs in chronic hepatitis B and HBV in vitro models.

About the authors

D. S. Kostyushev

Central Research Institute of Epidemiology

Author for correspondence.
Email: dk@rcvh.ru
Россия

A. P. Zueva

Central Research Institute of Epidemiology; M.V. Lomonosov Moscow State University

Email: noemail@neicon.ru
Россия

S. A. Brezgin

Central Research Institute of Epidemiology; I.M. Sechenov First State Medical University

Email: noemail@neicon.ru
Россия

A. D. Lipatnikov

Central Research Institute of Epidemiology; D.I. Mendeleev University of Chemical Technology of Russia

Email: noemail@neicon.ru
Россия

E. V. Volchkova

I.M. Sechenov First State Medical University

Email: noemail@neicon.ru
Россия

V. V. Maleyev

Central Research Institute of Epidemiology

Email: noemail@neicon.ru
Россия

V. P. Chulanov

Central Research Institute of Epidemiology; I.M. Sechenov First State Medical University

Email: noemail@neicon.ru
Россия

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Copyright (c) 2018 Kostyushev D.S., Zueva A.P., Brezgin S.A., Lipatnikov A.D., Volchkova E.V., Maleyev V.V., Chulanov V.P.

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