PHYLOGENETIC ANALYSIS OF BOVINE PESTIVIRUSES DETECTED IN SIBERIA

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Abstract

The results of phylogenetic analysis of three species of bovine pestiviruses circulating in six regions of Siberia, as well as those detected in fetal embryonic serum (FBS) and continuous cell cultures, are presented. The typing was made based on comparison of sequences from the 5' untranslated region (5'-UTR) of the viral genome. Among the highly productive dairy cattle, circulation of five subtypes of the BVDV1 (a, b, d, f, r) and BVDV2 was established. The predominant subtype was 1b (48% positive samples). The number of subtypes of BVDV1 was as follows: BVDV1: 1а (8%), 1b (48%), 1d (8%), 1f (16%) и 1r (8%) and BVDV2 (12%). Cell cultures revealed BVDV1a. The distribution of types and subtypes of viruses had geographical differences. BVDV1b, BVDV1d, BVDV1f и BVDV1r were detected in cattle or persistently infected (PI) animals in farms with respiratory distress. BVDV 1a revealed in the serum of PI heifer without manifestation of clinical symptoms. BVDV2 were detected in cattle with pathology of reproduction. The presence of the BVDV3 (atypical pestivirus) of the Italian group was established in seven lots of FBS obtained from two manufacturers. No evidence has been found for circulating of the atypical virus among cattle of various breeds, including imported, reindeers and red deers. Studies on the molecular epizootology of pestiviruses can be used to select and optimize the control strategy and address the issue of vaccine use in a particular region.

About the authors

A. G. Glotov

Siberian Federal Scientific Centre of Agro-biotechnologies, Institute of Experimental Veterinary Science of Siberia and the Far East

Author for correspondence.
Email: glotov_vet@mail.ru
Russian Federation

S. V. Koteneva

Siberian Federal Scientific Centre of Agro-biotechnologies, Institute of Experimental Veterinary Science of Siberia and the Far East

Email: noemail@neicon.ru
Russian Federation

T. I. Glotova

Siberian Federal Scientific Centre of Agro-biotechnologies, Institute of Experimental Veterinary Science of Siberia and the Far East

Email: noemail@neicon.ru
Russian Federation

A. G. Yuzhakov

D.I. Ivanovsky Institute of Virology, «National Research Center for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

R. A. Maksyutov

State Research Center of Virology and Biotechnology Vector

Email: noemail@neicon.ru
Russian Federation

A. D. Zaberezhnyy

All-Russian Research Institute of Experimental Veterinary Medicine named after Ya.R. Kovalenko

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2018 Glotov A.G., Koteneva S.V., Glotova T.I., Yuzhakov A.G., Maksyutov R.A., Zaberezhnyy A.D.

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