LUJO HEMORRHAGIC FEVER

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Abstract

Lujo hemorrhagic fever (LHF) is a viral disease accompanied with fever, headache, vomiting, diarrhea, arthralgia, myalgia and numerous signs of hemorrhagic syndrome. LHF causes a clinical syndrome remarkably similar to Lassa hemorrhagic fever. The first case of LHF occurred in Johannesburg, South Africa, in 2008. There was a secondary transmission from the index patient to four healthcare workers. Four of the five patients died. The etiologic agent of LHF is Lujo virus (LUJV) belonging to Arenavirus genus of the Arenaviridae Family. Virus Lujo is the second pathogenic arenavirus, after Lassa virus, to be recognized in Africa during the last 40 years. Data about epidemiology, clinical characteristics and diagnostics of LHF, properties of Lujo virus (according to phylogenetic analysis), and recommended precautions for preventing secondary transmission are considered in this paper.

About the authors

T. E. Sizikova

48th Central Scientific Research Institute

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

V. N. Lebedev

48th Central Scientific Research Institute

Email: noemail@neicon.ru
Russian Federation

S. I. Syromyatnikova

48th Central Scientific Research Institute

Email: noemail@neicon.ru
Russian Federation

S. V. Borisevich

48th Central Scientific Research Institute

Email: 48cnii@mil.ru
Russian Federation

References

  1. Paweska J.T., Sewlall N.H., Ksiazek T.G., Blumberg L.H., Hale M.J., lan Lipkin W., et al. Nosocomial outbreak of novel arenavirus infection, Southern Africa. Emerg. Inf. Dis. 2009; 15(10): 1596-602.
  2. Briese T., Paweska J.T., McMullan L.K., Hutchison S.K., Street C., Palacios G., et al. Genetic detection and characterization of Lujo virus, a new hemorrhagic fever - associated arenavirus from Southern Africa. PLoS Pathog. 2009; 5(5): 1-8.
  3. Buchmeier M.J, Peters C.J., de la Torre J.C. Arenavirdae: the viruses and their replication. In: Knipe D.M.H., Howley P.M., eds. Fields Virology. 5 th ed. Philadelphia: Lappincott, Williams and Wilkins; 2007: 1791-827.
  4. McLay L., Liang Y., Ly H. Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infection. J. Gen. Virol. 2014; 95(10): 1-15.
  5. Igonet S., Vaney M.C., Vonrhein C., Bricogne G., Stura E.A., Hengartner H., et al. X- raystructure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation. PNAS. 2011; 108(50): 19967-72.
  6. Lenz O., ter Meulen J., Feldman H., Klenk H. Garten W. Identification of a novel consensus sequence at the cleavage site of the Lassa virus glycoprotein. J. Virol. 2000; 74: 11418-21.
  7. York J., Nunberg J.H. A novel zinc-binding domain is essential for formation of the functional Junin virus envelope glycoprotein complex. J. Virol. 2007; 81(24): 13385-91.
  8. Bederka L.H., Bonhomme C.J., Ling E.L., Buchmeier M.J. Arenavirus stable signal peptide is the keystone subunit for glycoprotein coplex organization. MBio. 2014; 5(6): 1-14.
  9. Cajimat M.N.B. Genetic diversity and taxonomical relationships among the Tacaribe serocomplex viruses (family arenaviridae): Diss. Texas; 2007.
  10. Львов Д.К., Щелканов М.Ю. Аренавирусы. В кн.: Львов Д.К., ред. Руководство по вирусологии. Вирусы и вирусные инфекции человека и животных. М.: Медицинское информационное агентство; 2013: 271-4
  11. Bergeron E., Chakrabarti A.K., Bird B.H., Dodd K.A., McMullan L.K., Spiropoulou C.F., et al. Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth. J. Virol. 2012; 86(19): 10759-65.
  12. Atkinson B., Chamberlain J., Dowall S.D., Cook N., Bruce C., Hewson R. Rapid molecular detection of Lujo virus RNA. J. Virol. Methods. 2014; 195: 170-3.
  13. Ishii A., Thomas Y., Moongra L., Nakamura I., Ohnuma A. Novel arenavirus Zambia Emerging. Inf. Dis. 2011; 17(10): 1921-4.
  14. Tani H. Analyses of entry mechanisms of novel emerging viruses using pseudotype VSV system. Trop. Med. Health. 2014; 42(2): 71-82.
  15. Vela E. Animal models, profilaxis, and therapeutics for arenavirus infection. Viruses. 2012; 4(9): 1802-29.
  16. Bird B.H., Dodd K.A., Erickson B.R., Albarino C.G., Chakrabarti A.K., McMullan L.K., et al. Severe hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virus. PLoS Negl. Trop. Dis. 2012; 6(8): 1-13.
  17. Rasmussen A.L., Safronetz D., Proll S.C., Belisle S.E., Bryan J.T., Carter V.S., et al. Transcriptional signatures of lethality in Macaca fascicularis models of Lujo virus and Lassa virus infection. 5th International Conference on Primate Genomics. Human Genome Sequencing Center Baylor College of Medicine. Available at: http://www.primategenomics2012.com
  18. Rasmussen A.L., Tchitchek N., Safronetz D., Carter V.S., Williams C.M., Haddock E., et al. Delayed inflammatory and cell death responses are associated with reduced pathogenicity in Lujo virus-infected Cynomolgus Macaques. J. Virol. 2015; 89(5): 2543-52.
  19. Sewlall N.H., Richards G., Duse A., Swanepoel R., Paweska J., Blumberg L., et al. Clinical features and patient management of Lujo hemorrhagic fever. PLoS Negl. Trop. Dis. 2014; 8(11): 1-11.
  20. Tani H., Iha K., Shimojima M., Fukushi S., Taniguchi S., Yochikawa T., et al. Analysis of Lujo virus cell Entry using pseudotype vesicular stomatitis virus. J. Virol. 2014; 88(13): 7317-30.
  21. Zapata J.C., Cox D., Salvato M. The role of platelets in the pathogenesis of viral hemorrhagic fever. PLoS Negl. Trop. Dis. 2014; 8(6): 1-12.

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Copyright (c) 2017 Sizikova T.E., Lebedev V.N., Syromyatnikova S.I., Borisevich S.V.

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