Efficacy of Anti-Neuraminidase Drugs Application during and after an Influenza Pandemic


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Abstract

The emergent 2009 A(H1N1) pandemic brought into acute focus the problem of choosing the most effective anti-influenza drugs for successive influenza infection spreading control. Oseltamivir and zanamivir, influenza virus neuraminidase inhibitors (NAIs), were recommended by the WHO experts for the treatment and prevention of influenza, including that caused by pandemic strains. A major concern regarding the use of specific antiviral compounds is the emergence of the drug-resistant strains. Oseltamivir carboxylate and zanamivir IC 50 values were equal to 0.3-5.2 pM for the most of A(H1N1)pdm09 pandemic strains and 1.6-8.6 pM for the strains of influenza B virus in cell-based ELISA assay (2009-2010 season). All the studied strains of influenza A(H1N1)pdm09 (151) and B (22) viruses were sensitive to NAIs (2009-2011 seasons). For the first time in Russia oseltamivir-resistant A(H1N1) pdm09 influenza virus was isolated from the patient on the 5th day of a treatment course of this drug.

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Эффективность применения антинейраминидазных химиопрепаратов во время пандемии гриппа и в постпандемический период
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References

  1. Ленева И. А., Федякина И. Т., Еропкин М. Ю и др. Изучение противовирусной активности отечественных противогриппозных химиопрепаратов в культуре клеток и на модели животных. Вопросы вирусологии. 2010; 3. 19—27.
  2. Львов Д. К., Бурцева Е. И., Щелканов М. Ю. и др. Распространение нового пандемического вируса гриппа A(H1N1)v в России. Вопросы вирусологии. 2010; 3: 4—9.
  3. Calatayud L., Lackenby A., Reynolds A. et al. Oseltamivir-resistant pandemic (H1N1) 2009 virus infection in England and Scotland, 2009—2010. Emerg. Infect. Dis. 2011; 17: 1807—1815.
  4. Dapat C., Suzuki Y., Saito R. et al. Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs. Emerg. Infect. Dis. 2010; 16: 493—496.
  5. Duan S., Boltz D.A., Seiler P. et al. Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets. PLoS Pathog. 2010; 6 (7): e1001022.
  6. Gaur A.H., Bagga B., Barman S. et al. Intravenous zanamivir for oseltamivir-resistant 2009 H1N1 influenza. N. Engl. J. Med. 2010; 362: 88-89.
  7. Govorkova E. A., Leneva I. A., Goloubeva O. G. et al. Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses. Antimicrob. Agents Che-mother. 2001; 45: 2723—2732.
  8. Gubareva L. V., Matrosovich M. N., Brenner M. K. et al. Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus. Emerg. Infect. Dis. 1998; 178. 1257—1262.
  9. Gubareva L. V. Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors. Virus Res. 2004; 103: 199—203.
  10. Leneva I. A., Roberts N., Govorkova E. A. et al. The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/ Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Antiviral Res. 2000; 48: 101—115.
  11. McKimm-Breschkin J. L. Resistance of influenza viruses to neuraminidase inhibitors — a review. Antiviral Res. 2000; 47: 1—17.
  12. McKimm-Breschkin J., Trivedi T., Hampson A. et al. Neuraminidase sequence analysis and susceptibilities of influenza virus clinical iso lates to zanamivir and oseltamivir. Antimicrob. Agents Chemother. 2003; 47: 2264—2272.
  13. Mishin V. P., Hayden F G., Gubareva L. V. Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors. Antimicrob. Agents Chemother. 2005; 11: 4515—4520.
  14. MMWR. Update: Drug susceptibility of swine-origin influenza A(H1N1) viruses. Morbid. Mortal. Wkly Rep. 2009; 58: 433—435. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5816a6.htm.
  15. Moscona A. Neuraminidase Inhibitors for Influenza. N. Engl. J. Med. 2005; 353: 1363—1373.
  16. Renaud C., Boudreault A. A., Kuypers J. et al. H275Y mutant pandemic (H1N1) 2009 virus in immunocompromised patients. Emerg. Infect. Dis. 2011; 17: 653—660.
  17. Shin S. Y., Kang C., Gwack J. et al. Drug-resistant pandemic (H1N1) 2009, South Korea. Emerg. Infect. Dis. 2011; 17: 702—704.
  18. Sleeman K., Sheu T. G., Moore Z. et al. Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010—2011. Emerg. Infect. Dis. 2011; 17: 2043—2046.
  19. Sugaya N., Ohashi Y. Long-acting neuraminidase inhibitor laninamivir octanoate (CS-8958) versus oseltamivir as treatment for children with influenza virus infection. Antimicrob. Agents Chemother. 2010; 54: 2575—2582.
  20. Tramontana A. R., George B., Hurt A. C. et al. Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus, Australia. Emerg. Infect. Dis. 2010; 16: 1068— 1075.
  21. Ujike M., Ejima M., Anraku A. et al. Monitoring and characterization of oseltamivir-resistant pandemic (H1N1) 2009 virus, Japan, 2009—2010. Emerg. Infect. Dis. 2011; 17; 470—479.
  22. Weekly Epidemiol. Rec. 2011; 45: 497—508. http://www.who.int/ wer.
  23. WHO. CDC protocol of real-time RTPCR for swine influenza A(H1N1). // 28 April 2009. http://www.who.int/csr/disease/swineflu/ en/index.html.
  24. WHO (EuroFlu.org). Еженедельный электронный бюллетень ЕРБ ВОЗ. http://www.euroflu.org/cgi-files/bulletin_v2.cgi.-R353.-09 апреля 2010.
  25. WHO. Influenza A(H1N1) Virus Resistance to Oseltamivir: 2008 Southern HemisphereInfluenzaSeason. http://www.who.int/csr/ disease/influenza/oseltamivir_summarysouth2008/en/index.html.-2008.
  26. Yi H., Lee J. Y., Hong E. H. et al. Oseltamivir-resistant pandemic (H1N1) 2009 virus, South Korea. Emerg. Infect. Dis. 2010; 16: 1938—1942.

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Copyright (c) 2013 Breslav N.V., Shevchenko E.S., Abramov D.D., Prilipov A.G., Zhuravleva M.M., Oskerko T.A., Kolobukhina L.V., Merkulova L.N., Shchelkanov M.Y., Burtseva E.I., Lvov D.K.

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