Maternal and neonatal nevirapin resistance


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Abstract

The debatable article gives new evidence for the possibility, conditions, and resistance rate of the resistance to nevirapine, which results from its single use during labor for the prevention of vertical HIV transmission. The author analyzes the results of the 2009-2010 studies dealing with the use of high-sensitive methods for mutation detection, the impact of minor mutations on therapeutic effectiveness, and the evaluation of the effect of therapeutic support. She expressed the idea that it is expedient to test HIV for nevirapine resistance mutations in different periods after single administration of the drug as a prophylactic agent, the possible effects and algorithm of treatment if the above mutations are detected.

References

  1. Arrivé E., Newell M. L., Ekouevi D. K. et al. Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a meta-analysis // Int. J. Epidemiol. - 2007. - Vol. 36, N 5. - P. 1009-1021.
  2. Church J. D., Huang W., Parkin N. et al. Comparison of laboratory methods for analysis of non-nucleoside reverse transcriptase inhibitor resistance in Ugandan infants // AIDS Res. Hum. Retrovirus. - 2009. - Vol. 25, N 7. - P. 657-663.
  3. Coovadia A., Hunt G., Abrams E. J. et al. Persistent minority K103N mutations among women exposed to single-dose nevirapine and virologic response to nonnucleoside reverse-transcriptase inhibitor-based therapy // Clin. Infect. Dis. - 2009. - Vol. 48, N 4. - P. 462-472.
  4. Eshleman S. H., Mracna M., Guay L. A. et al. Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012) // AIDS. - 2001. - Vol. 15. - P. 1951-1957.
  5. Farr S. L., Nelson J. A. E., Ng'ombe T. J. et al. Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi // J. Acquir. Immune Defic. Syndr. - 2010. - Vol. 54. - P. 5!5-523.
  6. Flys T. S., Donnell D., Mwatha A. et al. Persistence of K103N-containing HIV-1 variants after single-dose nevirapine for prevention of HIV-1 mother-to-child transmission // J. Infect. Dis. - 2007. - Vol. 195, N 5. - P. 711-715.
  7. Hauser A., Mugenyi K., Kabasinguzi R. et al. Detection and quantification of minor human immunodeficiency virus type 1 variants harboring K103N and Y181C resistance mutations in subtype A and D isolates by allele-specific real-time PCR // Antimicrob. Agents Chemother. - 2009. - Vol. 53, N 7. - P. 2965-2973.
  8. Hudelson S., McConnell M., Bagenda D. et al. Emergence and persistence of nevirapine resistance in breast milk after single-dose nevirapine administration // AIDS. - 2010. - Vol. 24, N 4. - P. 557-561.
  9. Jourdain G., Wagner T. A., Ngo-Giang-Huong N. et al. Association between detection of HIV-1 DNA resistance mutations by a sensitive assay at initiation of antiretroviral therapy and virologic failure // Clin. Infect. Dis. - 2010. - Vol. 50, N 10. - P. 1397-1404.
  10. Lockman S., Shapiro R. L., Smeaton L. M. et al. Response to antiretroviral therapy after a single, peripartum dose of nevirapine // N. Engl. J. Med. - 2007. - Vol. 356. - P. 135-147.
  11. Lockman S., Hughes M. D., McIntyre J. et al. Antiretroviral therapies in women after single-dose nevirapine exposure // N. Engl. J. Med. - 2010. - Vol. 363. - P. 1499-1509.
  12. MacLeod I. J., Rowley C. F., Thior I. et al. Minor resistant variants in nevirapine-exposed infants may predict virologic failure on nevirapine-containing ART // J. Clin. Virol. - 2010. - Vol. 48, N 3. - P. 162-167.
  13. Palmer S., Boltz V., Martinson N. et al. Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission // Proc. Natl. Acad. Sci. USA. - 2006. - Vol. 103, N 18. - P. 7094-7099.
  14. Palumbo P., Lindsey J. C., Hughes M. D. et al. Antiretroviral treatment for children with peripartum nevirapine exposure // N. Engl. J. Med. - 2010. - Vol. 363. - P. 1510-1520.
  15. Rowley C. F., Boutwell C. L., Lee E. J. et al. Ultrasensitive detection of minor drug-resistant variants for HIV after nevirapine exposure using allele-specific PCR: clinical significance // AIDS Res. Hum. Retrovirus. - 2010. - Vol. 26, N 3. - P. 293-300.
  16. Stringer J. S., McConnell M. S., Kiarie J. et al. Effectiveness of non-nucleoside reverse-transcriptase inhibitor-based antiretroviral therapy in women previously exposed to a single intrapartum dose of nevirapine: a multi-country, prospective cohort study // PloS Med. - 2010. - Vol. 7. - N 2. - e1000233.
  17. Wagner T. A., Kress C. M., Beck I. et al. Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay // J. Clin. Microbiol. - 2010. - Vol. 48, N 5. - P. 1555-1561.

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Copyright (c) 2011 Bobkova M.R., Bobkova M.R.

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