Preclinical studies of live intranasal H5N1 influenza vaccine with the deleted HS1 gene


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Abstract

The paper gives the results of evaluating the efficiency of delNS1 pandemic H5N1 vaccine candidate VN1203delNS1 which was constructed by reverse genetics on the basis of influenza virus strain A/Vietnam/1203/04. The safety, immunogenicity and cross-protection of the vaccine strain against different H5N1 virus clades were demonstrated in mouse and macaque models. The results showed the possibility of designing a new-generation replication-deficient intranasal influenza vaccine, by applying an approach to deleting the NS1 pathogenicity factor, an antagonist of the interferon system.

References

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Copyright (c) 2011 Romanovskaya-Roman'ko E.A., Ferko V., Vyshemirskiy O.I., Romanova Y.P., Krenn V., Muster T., Grudinin M.P., Lapin B.A., Egorov A.Y., Kiselev O.I., Romanovskaya-Romanko E.A., Ferko B., Vyshemirsky O.I., Romanova Y.R., Krenn B., Muster T., Grudinin M.P., Lapin B.A., Egorov A.Y., Kiselev O.I.

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