Comparative evaluation of Leningrad-3 mumps vaccine virus neurovirulence in a neonatal rat model


Cite item

Full Text

Abstract

The neurovirulence and replication potential of several mumps virus strains, including Leningrad-3 mumps vaccine virus (FSUE SIC "Microgen", Russia) and wild type strains isolated in the Novosibirsk Region (Russia), were assessed in rat tests. The mean neurovirulence scores of the Leningrad-3 virus ( < 4.0) were significantly lower than those of wild type strains (ranging from 6.1 to 15.2) and were in accordance with the scores determined for other attenuated mumps vaccine strains (usually ranging from 0 to 5). In general, the relative ability of the viruses to replicate in the rat brain tracked with their neurovirulence scores. These results indicate a low neurovirulence potential of the Leningrad-3 mumps vaccine virus for humans.

References

  1. Максимова О. А., Попов В. Ф., Бектимиров Т. А. и др. Сравнительная оценка нейровирулентности отечественной и зарубежных живых паротитных вакцин // Вопр. вирусол. - 2001. - № 5. - С. 31-35.
  2. Смородинцев А. А. Непригодность теста нейровирулентности для оценки безвредности вакцинных штаммов вируса паротита // Труды Института им. Пастера. - 1979. - Т. 53. - С. 101-103.
  3. Afzal M. A., Buchanan J., Heath A. B., Minor P. D. Clustering of mumps virus isolates by SH gene sequence only partially reflects geographic origin // Arch. Virol. - 1997. - Vol. 142. - P. 227-238.
  4. Afzal M. A., Marsden S., Hull R. M. et al. Evaluation of the neurovirulence test for mumps vaccines // Biologicals. - 1999. - Vol. 27. - P. 43-49.
  5. Amexis G., Rubin S., Chatterjee N. et al. Identification of a new genotype H wild-type mumps virus strain and its molecular relatedness to other virulent and attenuated strains // J. Med. Virol. - 2003. - Vol. 70. - P. 284-296.
  6. Atrasheuskaya A. V., Kulak M. V., Rubin S., Ignatyev G. M. Mumps vaccine failure investigation in Novosibirsk, Russia, 2002-2004 // Clin. Microbiol. Infect. - 2007. - Vol. 13. - P. 670-676.
  7. Maximova O., Dragunsky E., Taffs R. et al. Monkey neurovirulence test for live mumps vaccine // Biologicals. - 1996. - Vol. 24. - P. 223-234.
  8. Norman G. R., Streiner D. L. Biostatistics. The bare essentials. - 2-nd ed. - London, 2000.
  9. Rafiefard F., Johansson B., Tecle T., Orvell C. Characterization of mumps virus strains with varying neurovirulence // Scand. J. Infect. Dis. - 2005. - Vol. 37. - P. 330-337.
  10. Rubin S. A., Pletnikov M., Carbome K. M. Comparison of the neurovirulence of a vaccine and a wild-type mumps virus strains in the developing rat brain // J. Virol. - 1998. - P. 8037- 8048.
  11. Rubin S. A., Snoy P., Wright K. E. et al. The mumps virus neurovirulence safety test in rhesus monkeys: a comparison of mumps virus strains // J. Infect. Dis. - 1999. - Vol. 180. - P. 521-525.
  12. Rubin S. A., Pletnikov M., Taffs R. et al. Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans // J. Virol. - 2000. - Vol. 74. - P. 5382-5384.
  13. Rubin S. A., Afzal M. A., Powell C. L. et al. The rat-based neurovirulence safety test for the assessment of mumps virus neurovirulence in humans: an international collaborative study // J. Infect. Dis. - 2005. - Vol. 191. - P. 1123-1128.
  14. Sauder C. J., Vandenburgh K. M., Iskow R. C. et al. Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity // Virology. - 2006. - Vol. 350. - P. 48-57.
  15. Tecle T., Johansson B., Jejcic A. et al. Characterization of three co-circulating genotypes of the small hydrophobic protein gene of mumps virus // J. Gen. Virol. - 1998. - Vol. 79. - P. 2929-2937.
  16. Tecle T., Böttiger B., Orvell C., Johansson B. Characterization of two decades of temporal co-circulation of four mumps virus genotypes in Denmark: identification of a new genotype // J. Gen. Virol. - 2001. - Vol. 82. - P. 2675-2680.
  17. IABS Scientific Workshop on Neurovirulence Tests for live virus vaccines. WHO, Geneva, Switzerland. - WHO. - 2005. - P. 1-7.
  18. WHO. Global advisory committee on vaccine safety. - Geneva, Switzerland, 12-13 June 2007.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Ignat'ev G.M., Otrashevskaya E.V., Rubin S.A., Ignatyev G.M., Atrasheuskaya A.V., Rubin S.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-77676 от 29.01.2020.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies