Impact of asymptomatic herpesvirus infection on the female reproductive system


Cite item

Full Text

Abstract

The fact that asymptomatic and subclinical isolation of the virus in the infected, which is, according to the data of different authors, noted in 50-90% of cases, presents the highest hazard to the spread of herpesvirus infection may be now considered to be proven. The development of assisted reproductive technologies have led to the active study of the factor of male infertility in marriage, including that of the negative impact of asymptomatic infection caused by herpes simplex virus (HSV) on spermatogenesis. At the same time, there is no consent of opinion as to the implication of asymptomatic HSV in female reproductive dysfunction. The presented review attempts to analyze the data available in the literature on the detection of HSV in the reproductive organs of a woman without a history of the clinical episodes of the disease and to assess a role of HSV infection in the development of female infertility.

References

  1. Абдулмеджидова А. Г., Курило Л. Ф., Шилейко Л. В. и др. Связь бессимптомной формы генитального герпеса с бесплодием у мужчин / Урология. - 2007. - № 3. - С. 56-59.
  2. Абдулмеджидова А. Г., Торганова И. Г., Витязева И. И. и др. Влияние бессимптомной формы герпесвирусной инфекции на результаты лечения бесплодия методами вспомогательных репродуктивных технологий // Акуш. и гин. - 2009. - № 1. - С. 45-48.
  3. Бочарова Е. Н., Абдумаликов Р. А., Брагина Е. Е. и др. Обнаружение белков и капсидов ВПГ в сперматозоидах человека // Докл. АН (клеточная биология). - 2003. - Т. 391, № 6. - С. 836-841.
  4. Бочарова Е. Н., Климова P. P., Завалишина Л. Э. и др. Выявление ДНК вируса простого герпеса в сперматозоидах человека методом гибридизации in situ //Материалы Всероссийской науч.-практ. конф "Медицинская микробиология - XXI век". - Саратов, 2004. - С. 44-45.
  5. Бочарова Е. Н., Брагина Е. Е., Гусак Ю. К. Герпетическое инфицирование сперматозоидов при неудачах использования репродуктивных технологий и спонтанном прерывании беременности // Урология. - 2007. - № 3. - С. 59-63.
  6. Долгушина Н. В., Макацария А. Д. Вирусные инфекции у беременных: Руководство для врачей. - М., 2004.
  7. Исаков В. А., Сельков С. А., Мошетова Л. К., Чернакова Г. М. Современная терапия герпесвирусных инфекций: Руководство для врачей - СПб.; М., 2004.
  8. Марченко Л. А. Генитальная герпетическая инфекция у женщин (клиника, диагностика, лечение): Дис. ... д-ра мед. наук. - М., 1997.
  9. Мейл Д., Бросторфф Дж., Рот Д. Б., Ройт А. Иммунология: Пер. с англ. - М., 2007.
  10. Милованов А. П. Патология системы мать-плацента- плод: Руководство для врачей. - М., 1999.
  11. Прилепская В. Н. Поликлиническая гинекология. - М., 2004.
  12. Barton I. G., Najem S. N., Walker M. J., Potter C. W. Isolation and characterisation of two strains of Herpesvirus hominis type 1 from fallopian tubes // J. Med. Microbiol. - 1982. - Vol. 15, N 1. - P. 63-71.
  13. Barton S., Munday P., Patel R. Asymptomatic shedding of herpes simplex virus from the genital tract: uncertainty and its consequences for patient management. The Herpes simplex virus Advisory Panel // Int. J. STD AIDS. - 1996. - Vol. 7. - P. 229-232.
  14. Bendon R. W., Perez F., Ray M. B. Herpes simplex virus: fetal and decidual infection // Pediatr. Pathol. - 1987. - Vol. 7, N 1. - P. 63-70.
  15. Bezold G., Politch J. A., Kiviat N. B. et al. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia // Fertil. and Steril. - 2007. - Vol. 87, N 5. - P. 1087-1097.
  16. Blanco O., Tirado I., Munoz-Fernandez R. et al. Human decidual stromal cells express HLA-G: Effects of cytokines and decidualization // Hum. Reprod. - 2008. - Vol. 23, N 1. - P. 144-152.
  17. Chatterjee A., Chartrand S. A., Harrison C. J. et al. Severe intrauterine herpes simplex disease with placentitis in a newborn of a mother with recurrent genital infection at delivery // J. Perinatol. - 2001. - Vol. 21, N 8. - P. 559-564.
  18. Csata S., Kulcsar G. Virus-host studies in human seminal and mouse testicular cells // Acta Chir. Hug. - 1991. - Vol. 32. - P. 83-90.
  19. Diguet A., Patrier S., Eurin D. et al. Prenatal diagnosis of an exceptional intrauterine herpes simplex type 1 infection // Prenat. Diagn. - 2006. - Vol. 26, N 2. - P. 154-157.
  20. el Borai N., Inoue M., Lefйvre C. et al. Detection of herpes simplex DNA in semen and menstrual blood of individuals attending an infertility clinic // J. Obstet. Gynaecol. Res. - 1997. - Vol. 23, N 1. - P. 17-24.
  21. el Borai N., Lefйvre C., Inoue M. et al. Presence of HSV-1 DNA in semen and menstrual blood // J. Reprod. Immunol. - 1998. - Vol. 41, N 1-2. - P. 137-147.
  22. Gillgrass A. E., Fernandez S. F., Rosental K. L., Kaushic C. Estradiol regulates sussceptibility following primary exsposure to genital herpes simplex virus type 2, while progesterone induce inflomation // J. Virol. - 2005. - P. 3107-3116.
  23. Halioua В., Malkin J. Epidemiology of genital herpes - recent advances // Eur. J. Dermatol. - 1999. - Vol. 9. - P. 177- 184.
  24. Hutto C., Arvin A., Jacobs R. et al. Intrauterine herpes simplex virus infections / J. Pediatr. - 1987. - Vol. 110, N 1. - P. 97-101.
  25. Hyde S. R., Giacoia G. P. Congenital herpes infection: placental and umbilical cord findings // Obstet. and Gynecol. - 1993. - Vol. 81, N 5, Pt 2. - P. 852-855.
  26. Kalu E., Bhaskaran S., Thum M. Y. et al. Serial estimation of Th1 : Th2 cytokines profile in women undergoing in vitro fertilization - embryo transfer // Am. J. Reprod. Immunol. - 2008. - Vol. 59, N 3. - P. 206-211.
  27. Kapranos N., Petrakou E., Anastasiadou C., Kotronias D. Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic // Fertil and Steril. - 2003. - Vol. 79. - Suppl. 3. - P. 1566-1770.
  28. Kawana T. Vertical transmission of alpha herpes virus / Nippon Rinsho. - 2000. - Vol. 58, N 4. - P. 871-876.
  29. Kotronias D., Kapranos N. Detection of herpes simplex virus DNA in human spermatozoa by in situ hybridization technique // In vivo. - 1998. - Vol. 12, N 4. - P. 391-394.
  30. Krause W., Herbstreit F., Slenzka W. Are viral infections the cause of leukocytospermia? // Andrologia. - 2002. - Vol. 34, N 2. - P. 87-90.
  31. Kulcsдr G., Dцmцtцri J., Dдn P. et al. Virological studies on gynaecological patients // Zbl. Bakteriol. (Orig. А). - 1975. - Bd. 231, N 4. - S. 389-392.
  32. Lefrancq Т., Orain I., Michalak S. et al. Herpetic salpingitis and fallopian tube prolapse // Histopathology. - 1999. - Vol. 34, N 6. - P. 548-550.
  33. Lehtinen M., Rantala I., Teisala K. et al. Detection of herpes simplex virus in women with acute pelvic inflammatory disease // J. Infect. Dis. - 1985. - Vol. 152, N 1. - P. 78-82.
  34. Li D., Huang Т., Zhang Z. The relationship between herpes simplex virus II, human papillomavirus infection and infertility after artificial abortion // Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. - 1998. - Vol. 12, N 2. - P. 155-157.
  35. McDonagh S., Maidji E., Ma W. et al. Viral and bacterial pathogens at the maternal-fetal interface // J. Infect. Dis. - 2004. - Vol. 190, N 4. - P. 826-834.
  36. Mac Donald E. M., Savoy A., Gillgrass A. et al. Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection // Biol. Reprod. - 2007. - Vol. 77, N 6. - P. 1049-1059.
  37. Mцller B. R. Herpes simplex infection in pregnant women and newborn infants // Ugeskr. Laeger. - 1995. - Vol. 157, N 7. - P. 903-904.
  38. Moore D., Campero C., Odeon A. et al. Humoral immune response to infectious agents in aborted bovine fetuses in Argentina // Rev. Argent Microbiol. 2003. - Vol. 35. - P. 143-148.
  39. Osatanin A. A., Aizikovich B. I., Aizikovich I. V. et al. Role of cytokines in the regulation of reproductive function // Bull. Exp. Biol. Med. - Vol. 143, N 1. - P. 75-79.
  40. Overall J. C. Jr. Herpes simplex virus infection of the fetus and newborn / Pediatr. Ann. - 1994. - Vol. 23, N 3. - P. 131-136.
  41. Pallier C., Tebourbi L., Chopineau-Prost S. et al. Herpesvirus, cytomegalovirus, human sperm and assisted fertilization / Hum. Reprod. - 2002. - Vol. 17, N 5. - P. 1281-1287.
  42. Ralph P., Braun, Lendon G. et al. Characterization of the IFN-г T-cell responses to immaediate early antigen in humans with genital herpes // Virol. J. - 2006. - Vol. 3. - P. 54.
  43. Rimdusit P., Yoosook C., Srivanboon S. et al. Prevalence of genital herpes simplex infection and abnormal vaginal cytology in late pregnancy in asymptomatic patients // Int. J. Gynaecol. Obstet. - 1989. - Vol. 30, N 3. - P. 231-236.
  44. Robb J. A., Benirschke K., Barmeyer R. Intrauterine latent herpes simplex virus infection: I. Spontaneous abortion // Hum.Pathol. - 1986. - Vol. 17, N 12. - P. 1196-1209.
  45. Robb J. A., Benirschke К., Mannino F. Voland J. Intrauterine latent herpes simplex virus infection: II. Latent neonatal infection // Hum. Pathol. - 1986. - Vol. 17, N 12. - P. 1210-1217.
  46. Rokos K., Wang H., Seeger J. et al. Transport of viruses through fetal membranes: an in vitro model of perinatal transmission // J. Med. Virol. - 1998. - Vol. 54, N 4. - P. 313-319.
  47. Salamonsen L. A., Hannan N. J., Dimitriadis E. Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation // Semin. Reprod. Med. - 2007. - Vol. 25, N 6. - P. 437-444.
  48. Stanberry L. R. Asymptomatic herpes simplex virus shedding and Russian roulette // Clin. Infect. Dis. - 2000. - Vol. 30. - P. 268-269.
  49. Svend Ellermann-Erisken. Macrophages and cytokines in the early defence against herpes simplex virus // Virol. J. 2005. - Vol. 2. - P. 59.
  50. Thomas D., Michou V., Tegos V. et al. The effect of valacyclovir treatment on natural killer cells of infertile women // Am. J. Reprod. Immunol. - 2004. - Vol. 3. - P. 248-255.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Abdulmedzhidova A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-77676 от 29.01.2020.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies