Diagnostic advantages of the test system "DS-EIA-HBsAg-0.01" for detection of HBV surface antigen


Cite item

Full Text

Abstract

The new highly sensitive test system "DS-EIA-HBsAg-0.01" (Priority Certificate No. 2006129019 of August 10, 2006) in detecting hepatitis B surface antigen (HBsAg) was assessed. The sensitivity of the test was estimated using the federal standards sample HBsAg 42-28-311-06, panels' samples Boston Biomedica Inc. (West Bridgewater, Mass, USA) and ZeptoMetrix Corp. (Buffalo, NY, USA). The findings have indicated that "DS-EIA-HBsAg-0.01" is equally effective in detecting different subtypes of HBsAg during a seroconversion period earlier than alternative assays. Along with its high analytical and diagnostic sensitivity, the system shows a high diagnostic specificity.

References

  1. Hofer M., Joller-Jemelka H. I., Grob P. J. et al. Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen only. Swiss HIV Cohort Study // Eur. J. Clin. Microbiol. Infect. Dis. - 1998. - Vol. 17. - P. 6-13.
  2. Liang T. J., Blum H. E., Wands J. R. Characterization and biological properties of a hepatitis B virus isolated from a patient without hepatitis B virus serological markers // Hepatology. - 1990. - Vol. 12. - P. 204-212.
  3. Schuttler C. G., Fiedler N., Schmidt K. et al. Suppression of hepatitis B virus enhancer 1 and 2 by hepatitis C virus core protein // J. Hepatol. - 2002. - Vol. 37. - P. 855-862.
  4. Thiers V., Nakajima E., Kremsdorf D. et al. A transmission of hepatitis B from hepatitis-B-seronegative subjects // Lancet. - 1988. - Vol. 2. - P. 1273-1276.
  5. Wagner A. A., Loustaud-Ratti V., Chemin I. et al. Double hepatitis B virus infection in a patient with HIV/hepatitis C virus coinfection and "anti-HBc alone" as serological pattern // Eur. J. Clin. Microbiol. Infect. Dis. - 2005. - Vol. 24. - P. 623-627.
  6. Weinberger K. M., Bauer T., Bohm S., Jilg W. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HbsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HbsAg in serum // J. Gen. Virol. - 2000. - Vol. 81. - P. 1165-1174.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Egorova N.I., Pyrenkova I.Y., Igolkina S.N., Sharipova I.N., Puzyrev V.F., Obryadina A.P., Burkov A.N., Kornienko N.V., Howard A.F., Korovkin A.S., Shalunova N.V., Bektimirov T.A., Kuznetsov K.V., Koshcheeva N.A., Ulanova T.I., Yegorova N.I., Pyrenkova I.Y., Igolkina S.N., Sharipova I.N., Puzyrev V.F., Obryadina A.P., Burkov A.N., Kornienko N.V., Fields H.A., Korovkin A.S., Shalunova N.V., Bektimirov T.A., Kuznetsov K.V., Koshcheyeva N.A., Ulanova T.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-77676 от 29.01.2020.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies