Neuropathogenicity of Coxsackie B virus strains isolated from children with clinical manifestations of aseptic meningitis in different years

The neuropathogenicity of Coxsackie B3, B1, and B5 virus strains was studied in experimentally infected suckling BALB/c mice and in contact animals from the same nest and litter infected due to the natural virus spread. The similar neurological disorders were found in both groups of animals. The data on pathological and morphological changes in the medulla oblongata as dystrophic and necrotic changes in the neurons with their lysis and deletion, brain tissue edema, and hemodynamic changes confirmed the neutrotropicity of the strains under study. The revealed pattern of brain lesions did not depend on the time of isolation of the viral strains being examined.

Coxsackie B viruses, experiment, neuropathogenicity