The antiviral activity ofRNAse Bacillus intermedius in experiments with mice preinfected with street rabies virus

RNAse Bacillus intermedius, when administered once and according to 11 repeated experiments, protected the
preliminarily infected CBA mice with street rabies virus (protection of 40-67%; p < 0.01-0.001). A reliable protection
of Animals was registered only when RNAse was administered intramuscularly at the virus introduction spot; it
was not effective, when the bacterial RNAse was injected in the brain, vein, under the skin or in muscles of a noninfected extremity.
Neither did it produce any suppressive effect on the vaccinal antirabic immunity.

street rabie virus, experimental infection, RNase Bacillus intermedius, mice, antiviral activity, vaccinal immunity