Email this article Fullevir: In vitro and in vivo antiherpetic activity
- Issue: Vol 54, No 1 (2009)
- Pages: 4-
- Section: Articles
- URL: https://virusjour.crie.ru/jour/article/view/11886
- ID: 11886
Cite item
Full Text
Abstract
The antiherpetic properties of a fullerene derivative with aminocaproic acid (manufactured by Intelfarm Co. as Fullevir®) were studied in in vitro (in sensitive cell cultures) and in vivo (on a murine model of experimental herpetic encephalitis) experiments. Fullevir was found to protect tissue culture cells from the cytodestructive action of herpes simplex virus type 1. It was estimated that ED50 = 5.3 mg/ml and ED90 = 29.1 mg/ml. The agent was most effective when it was administered before and 30 minutes after cell culture infection.
The in vivo study established that Fullevir® showed a significant protective effect in experimental herpetic encephalitis. The protection rates were 29.8% and 41.0% with the total doses of Fullevir® of 500 mg/kg (p < 0.007) and 1000 mg/kg (p < 0.004), respectively. Thus, the in vitro and in vivo studies demonstrated the antiherpetic effect of a fullerene-aminocaproic acid complex (1-hydrofullereneaminocaproic acid, sodium salt) having the trade name Fullevir®.
The in vivo study established that Fullevir® showed a significant protective effect in experimental herpetic encephalitis. The protection rates were 29.8% and 41.0% with the total doses of Fullevir® of 500 mg/kg (p < 0.007) and 1000 mg/kg (p < 0.004), respectively. Thus, the in vitro and in vivo studies demonstrated the antiherpetic effect of a fullerene-aminocaproic acid complex (1-hydrofullereneaminocaproic acid, sodium salt) having the trade name Fullevir®.
References
- Меджидова М. Г., Абдуллаева М. В., Федорова Н. Е. и др. Противовирусная активность аминокислотных производных фуллерена при цитомегаловирусной инфекции in vitro // Антибиотики и химиотер. - 2004. - Т. 49, № 8-9. - С. 13-20.
- Пиотровский Л. Б., Козелецкая К. Н., Медведева Н. А. и др. Влияние комплекса фуллерена C60 с поливинилпирролидоном на репродукцию вирусов гриппа // Вопр. вирусол. - 2001. - № 3. - С. 38-42.
- Пиотровский Л. Б., Киселев О. И. Фуллерены в биологии. - СПб., 2006.
- Kasermann F., Kempf C. Buckminsterfullereneand pgotodynamic inactivation of viruses // Rev. Med. Virol. - 1998. - Vol. 8. - P. 143-151.
- Kroto H. W., Heath S., O'Brien S. C. et al. C60: Buckminsterfullerene // Nature. - 1985. - Vol. 19. - P. 162-163.
- Powell W. H., Cozzi F., Moss G. P. et al. // Nomenclature for the C60-Ih and C70-D5H(6) fullerenes (IUPAC Recoomendations 2002) // Pure Appl. Chem. - 2002. - Vol. 74. - P. 629-695.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).