Spectrumof cytokines produced by blood leukocytes in infection of herpes simplex virus, type 1


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Abstract

Three types of reaction of human blood leucocytes to herpes simplex virus 1 (HSV-1) were detected. The first reaction
type, i.e. production of IFN-a, IFN-y, IL-1(J, IL-6 and TNFa but not of IL-2 or lL-4, denotes the primary body
reaction to an infectious agent. The second reaction type is related with infection of activated HSV-1 leucocytes
and is accompanied by an inhibited production of IFN-y, IL-6 and IL-8, which is targeted at suppressing the antivirus
cell mechanisms. The third reaction type is associated with production of IFN-a, IFN-y, IL-p, IL-6 and TNFa
by blood leucocytes affected by HSV-1-infected leucocytes.

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