Email this article An experimental infection caused by the EP-2 strain of cowpox virus in different-age mice
- Issue: Vol 48, No 5 (2003)
- Pages: 34-38
- Section: Articles
- URL: https://virusjour.crie.ru/jour/article/view/11807
- ID: 11807
Cite item
Full Text
Abstract
The specificity of lethal infection was studied in noninbred white mice (age - 15 to 20 and 25 to 30 days) infected intraperitoneally with the EP-2 strain of cowpox virus (CPV) in doses 10s, 106 and 107 PFU. The virus caused the lethal infection in the 15-20-day mice; while the 25-30-day mice remained healthy and survived. Virologic, immunologic-and-histochemical and electron-microscopy examinations of the 15-20-day mice revealed a replication of the EP-2 strain in tissues bordering on the virus introduction area; there was no generalization of infection. The virus replicated first in the mesothelium cells, and after that, in fibroblasts as well as in the endothelial, fatty, adventicial, cross-striated and muscle cells and in myosatellites.
References
- Маренникова С. С., Щелкунов С. Н. Патогенные для человека ортопоксвирусы. - М., 1998. - С. 16-39.
- Уилки Б. Электронная микроскопия для начинающих. - М., 1975. - С. 287-288.
- Шелухина Э. М. Биология и экология ортопоксвирусов, патогенных для человека: Дис. ... д-ра мед. наук. - М., 1980.
- Baxby D., Ghaboosi В. Laboratory characteristics of poxviruses isolated from captive elephants in Germany // J. Gen. Virol. - 1977. - Vol. 37. - P. 407-414.
- Bray M., Martinez M., Smee D. F. et al. Codofovir protects mice against lethal aerosol or intranasal cowpox virus challenge // J. Infect. Dis. - 2000. - Vol. 181. - P. 10-19.
- Kochneva G., Urmanov I., Ryabchikova E. et al. Fine mechanisms of ectromelia virus thymidine kinase-negative mutants avirulence // Virus Res. - 1994. - Vol. 34. - P. 49-61.
- Martinez M. J., Bray M. P., Huggins J. W. A model of aerosoltransmitted orthpoxviral disease // Arch. Pathol. Lab. Med. - 2000. - Vol. 124. - P. 367-377.
- Meyer H., Neubauer H., Pfeffer M. Amplification of 'Variola virus-specific sequences in German cowpox virus isolates // J. Vet. Med. - 2002. - Vol. 49. - P. 17-19.
- Moss В., Poxviridae: The viruses and their replication // Fields Virology. - Philadelphia, 1996. - P. 2637-2659.
- Mutter G., Williamson J. D. Poxviridae // Animal Virus Structure. - Amsterdam, et al., 1987. - P. 421-433.
- Rayne L. G. The existence of an envelope on extracellular cowpox virus and its antigenic relationship to the vaccinia envelope // Arch. Virol. - 1986. - Vol. 90. - P. 125-133.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).