The comparative analysis of wild measles viruses strains isolated in the European Part of the Russian Federation


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Abstract

Eleven wild measles virus isolated, in 1988 and in 1999-2001 in the European territory of the Russian Federation, were investigated. On the basis of an analysis of N-gene region sequences, encoding the COOH terminal end of nucleoprotein, the isolates were divided into 2 subgroups. According to the WHO classification, subgroup 1 was in line with genotype A and subgroup 2 - with genotype D. Subgroup 2 was close to genotype D4 but differed from it according to its composition of nucleotides on the average by 2.8%, and according to its amino-acid composition - by 2.6%. with respect to the WHO criteria, the latter can be referred to prelimarily as an independent genotype. Finally, the measles viruses' strains of genetic groups A and D circulated in the Russian Federation in 1988, and in 1999-2001.

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Copyright (c) 2003 Zhuravleva Y.N., Lugovtsev V.Y., Voronina O.L., Shilov I.A., Vanyusheva O.V., Lunin V.G., Naumova M.A., Mamayeva T.A., Tikhonova N.T.

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