Email this article The immune response in oral and rectal immunization by the attenuated strain of Salmonella carrying the HIV DNA-vaccine
- Issue: Vol 48, No 4 (2003)
- Pages: 16-20
- Section: Articles
- Submitted: 09.06.2023
- Published: 15.08.2003
- URL: https://virusjour.crie.ru/jour/article/view/11783
- ID: 11783
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Abstract
The recombinant strain of Salmonella typhimurium SL7207/pBMC-env, carrying a plasmid containing the gene of protein HIV-1 gp-160, was obtained under the monitoring by CMV-promoter. The above strain was used in the rectal and oral immunization of BALB/c mice. HIV-specific antibodies were detected in serum after a one-time immunization; such antibodies were able to inhibit the viral replication in vitro. Furthermore, the shaping-up of the specific cytotoxic and of proliferative responses was registered. Finally, the rectal immunization by cells of the Salmonella recombinant strain can be regarded as a promising delivery system of DNA-vaccine (pBMC-env), and it is more effective versus the oral immunization variant.
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References
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).