Email this article Interaction of human apolipoptotein AI and of envelope proteins HIV-1 with the CD4 native and recombinant receptor
- Issue: Vol 49, No 1 (2003)
- Pages: 24-26
- Section: Articles
- Submitted: 09.06.2023
- Published: 15.02.2003
- URL: https://virusjour.crie.ru/jour/article/view/11758
- ID: 11758
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Abstract
The method of enzyme-linked immunosorbent assay (ELISA) was used to show an interaction of soluble recombinant CD4-receptor (rsCD4) with human apolipoprotein A-1. Competitive interactions between envelope proteins VIH-1 (gp120 and gp41), on the one hand, and human apolipoprotein A-1 with CD4 receptor, present in the cellular membranes of line MT4 human lymphocytes, were demonstrated by the method of flow cytofluorimetry. It was suggested that the competitive interactions between the above proteins could manifest in respect to the apolipoprotein A-1 receptor, which affects the involvement of the latter in the regulation of protein biosynthesis and which leads to a decrease in the body weight of HIV-infected patients.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).