Молекулярно-биологические свойства гена lmp1 вируса Эпштейна–Барр: структура, функции и полиморфизм

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Исследования последних лет свидетельствуют о том, что латентный мембранный белок 1 (LMP1), кодируемый одноименным геном вируса Эпштейна - Барр (ВЭБ), играет чрезвычайно важную роль в патогенезе ряда злокачественных неоплазий, что обусловлено свойствами этого вирусного онкобелка. в частности, LMP1 обладает способностью трансформировать в-лимфоциты человека in vivo и in vitro, а также фибробласты грызунов (Rat-1) in vitro, введение которых бестимусным мышам приводит к возникновению опухолей. Кроме того, экспрессию онкобелка часто обнаруживают в ВЭБ-ассоциированных опухолях на уровне ДНК и постоянно на уровне РНК. LMP1, оказывая плейотропное действие, участвует в передаче многочисленных внутриклеточных сигналов, активируя многие из них. Он также участвует в ингибировании ключевых опухолевых супрессоров, оказывает существенное влияние на пролиферацию, апоптоз, морфологические изменения инфицированных клеток, приводя в конечном счете к их трансформации. в предлагаемом обзоре дана общая характеристика ВЭБ, кратко описаны заболевания человека, ассоциированные с этим вирусом, представлена общая характеристика гена LMP1 и функциональная активность кодируемого им белка LMP1, подробно рассмотрен вопрос, касающийся полиморфизма LMP1 при ВЭБ-ассоциированных патологиях.

Об авторах

К. В. Смирнова

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»

Автор, ответственный за переписку.
Email: smirnovakv@rambler.ru

Смирнова Ксения Валерьевна, канд. биол.наук

115478, г. Москва

Россия

С. В. Дидук

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»

Email: fake@neicon.ru
115478, г. Москва Россия

Н. Б. Сенюта

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»

Email: fake@neicon.ru
115478, г. Москва Россия

В. Э. Гурцевич

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»

Email: fake@neicon.ru
115478, г. Москва Россия

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