HEMORRHAGIC FEVER WITH RENAL SYNDROME GROUP OUTBREAK CAUSED BY SOCHI VIRUS

T. K. Dzagurova; Дзагурова Т. К.; A. A. Ishmukhametov; Ишмухаметов А. А.; V. A. Bakhtina; Бахтина В. А.; V. G. Morozov; Морозов В. Г.; M. V. Balovneva; Баловнева М. В.; S. S. Kurashova; Курашова С. С.; B. .. Klempa; Клемпа Б. ..; D. .. Kruger; Кругер Д. ..; E. A. Tkachenko; Ткаченко Е. А.

doi:10.18821/0507-4088-2019-64-1-36-41

HEMORRHAGIC FEVER WITH RENAL SYNDROME GROUP OUTBREAK CAUSED BY SOCHI VIRUS

Authors: Dzagurova T.K.¹, Ishmukhametov A.A.¹^,2, Bakhtina V.A.³, Morozov V.G.⁴, Balovneva M.V.¹, Kurashova S.S.¹, Klempa B...⁵, Kruger D...⁶, Tkachenko E.A.¹^,2
Affiliations:
1. Chumakov federal scientific center for research and development of immune-and-biological products of Russian academy of sciences
2. 1th Moscow State medical university named by I.M. Sechenov
3. Specialized clinical infectious hospital
4. Medical Company «Gepatolog»
5. Biomedical Research Center Slovak Academy of Sciences
6. Institute of Virology, Helmut-Ruska-Haus
Issue: Vol 64, No 1 (2019)
Pages: 36-41
Section: ORIGINAL RESEARCH
URL: https://virusjour.crie.ru/jour/article/view/232
DOI: https://doi.org/10.18821/0507-4088-2019-64-1-36-41
ID: 232

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Abstract

Introduction. Hemorrhagic fever with renal syndrome (HFRS) occupies a leading place among natural focal human diseases in the Russian Federation. Sporadic incidence of HFRS-Sochi has been annually recorded in the Krasnodar Territory since 2000. The group outbreak of the HFRS-Sochi was first registered in Gelendzhik in the fall of 2013. Material and methods. Serological methods were used: indirect immunofluorescence, enzyme immunoassay, FRNT in Vero cells, and methods for the viral RNA detection: PCR and RT-PCR. Results. Data of clinical, epidemiological, immunological and molecular studies of 3 out of 4 cases in HFRS-Sochi outbreak are presented. Severity of the disease correlated with early gastrointestinal disorders appearance. Patient MA gastrointestinal disorders were joined on day 3 of a fever. Clinical and laboratory studies revealed signs of kidneys, liver, pancreas damage, bilateral hydrothorax, bilateral polysegmental pneumonia and polyneuropathy. As a result of long-term treatment, the patient recovered. Patient AA had gastrointestinal disturbances the next day after fever onset. The patient was not saved, despite early hospitalization. Hantavirus antigen and RNA were detected in the lung tissues 2 out of 10 Black-Sea field mice captured in the affected area, as well as in the organs of deceased patient. Discussion. The most severe clinical course of the disease in close relatives, son and father, with a fatal outcome in the latter case may be the result of genetic features. The severity and outcome of the disease was not depend on day of hospitalization and correlated with the early manifestations of gastrointestinal disorders. Conclusion. Presented data confirm high virulence and pantropism of the Sochi virus, as well as the epidemiological role of Black-Sea field mouse (Apodemus ponticus) as the host of the Sochi virus and the source of human infection.

Keywords

hantaviruses, Sochi virus, hemorrhagic fever with renal syndrome, Black-Sea field mouse

References

Ткаченко Е.А., Дзагурова Т.К., Бернштейн А.Д., Коротина Н.А., Окулова Н.М., Мутных Е.С. и др. Геморрагическая лихорадка с почечным синдромом (история, проблемы и перспективы изучения). Эпидемиология и вакцинопрофилактика. 2016; 15(3): 23-34.
Морозов В.Г., Ишмухаметов А.А., Дзагурова Т.К., Ткаченко Е.А. Клинические особенности геморрагической лихорадки с почечным синдромом в России. Медицинский совет. 2017; (5): 156-61.
Jiang H., Du H., Wang L.M., Wang P.Z., Bai X.F. Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. Front. Cell. Infect. Microbiol. 2016; 6: 1. doi: 10.3389/fcimb.2016.00001
Klempa B., Avsic-Zupanc T., Clement J., Dzagurova T.K., Henttonen H., Heyman P., et. al. Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics. Arch. Virol. 2013; 158(3): 521-9. doi: 10.1007/s00705-012-1514-5
Tkachenko E., Dzagurova T., Dekonenko A., Ivanov A., Yampolskiy A., Brudniy R., et al. First identified acute severe HFRS case in Russia caused by Dobrava hantavirus type and associated with Apodemus sylvaticus. In: Abstracts of 5th International Conference on HFRS, HPS, and hantaviruses. Veyrier-du-Lac, France; 2001: 24-7.
Дзагурова Т.К., Ткаченко Е.А., Юничева Ю.В., Морозов В.Г., Брюханов А.Ф., Башкирцев В.Н. и др. Обнаружение и клинико-этиологическая характеристика ГЛПСвсубтропической зоне Краснодарского края. Журнал микробиологии, эпидемиологии и иммунобиологии. 2008; (1): 12-6
Meisel H., Wolbert A., Razanskiene A., Marg A., Kazaks A., Sasnauskas K., et al. Development of novel immunoglobulin G (IgG), IgA, and IgM enzyme immunoassays based on recombinant Puumala and Dobrava hantavirus nucleocapsid proteins. Clin. Vaccine Immunol. 2006; 13(12): 1349-57. doi: 10.1128/CVI.00208-06
Kramski M., Meisel H., Klempa B., Krüger D.H., Pauli G., Nitsche A. Detection and typing of human pathogenic hantaviruses by real-time reverse transcription-PCR and pyrosequencing. Clin. Chem. 2007; 53(11): 1899-905. doi: 10.1373/clinchem.2007.093245
Tang Y.M., Yang W.S., Zhang W.B., Bai X.E. Localization and changes of hemorrhagic fever with renal syndrome virus in lymphocyte subpopulation. Cin. Med. J. (Engl.) 1991; 104(8): 673-8.
Kruger D.H., Tkachenko E.A., Morozov V.G., Yunicheva Y.V., Pilikova O.M., Malkin G., et al. Life-Threatening Sochi Virus Infections, Russia. Emerg. Infect. Dis. 2015; 21(12): 2204-8. doi: 10.3201/eid2112.150891
Ткаченко Е.А., Окулова Н.М., Юничева Ю.В., Морзунов С.П., Хайбулина С.Ф., Рябова Т.Е. и др. Эпизоотологические и вирусологические особенности природного очага хантавирусной инфекции в субтропической зоне Краснодарского края. Вопросы вирусологии. 2005; 50(3): 14-9
Dzagurova T.K., Witkowski P.T., Tkachenko E.A., Klempa B., Morozov V.G., Auste B., et al. Isolation of Sochi virus from a fatal case of hantavirus disease with fulminant clinical course. Clin. Infect. Dis. 2012; 54(1): 1-4. doi: 10.1093/cid/cir746
Avsic-Zupanc T., Petrovec M., Furlan P., Kaps R., Elgh F., Lundkvist A. Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia - a 10-year survey. Clin. Infect. Dis. 1999; 28(4): 860-5. doi: 10.1086/515185
Papa A., Antoniadis A. Hantavirus infections in Greece - an update. Eur. J. Epidemiol. 2001; 17(2): 189-94.
Слонова Р. А., Астахова Т. И., Компанец Г. Г. Результаты изучения геморрагической лихорадки с почечным синдромом на юге Дальнего Востока России. Журнал микробиологии, эпидемиологии и иммунобиологии. 1997; (5): 97-101
Zhang Y.Z., Zou Y., Fu Z.F., Plyusnin A. Hantavirus infections in humans and animals, China. Emerg. Infect. Dis. 2010; 16(8): 1195-203. doi: 10.3201/eid1608.090470
Noh J.Y., Cheong H.J., Song J.Y., Kim W.J., Song K.J., Klein T.A., et al. Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period. J. Clin. Virol. 2013; 58(1): 11-7. doi: 10.1016/j.jcv.2013.06.027
Mustonen J., Partanen J., Kanerva M., Pietilä K., Vapalahti O., Pasternack A., et al. Genetic susceptibility to sever course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int. 1996; 49(1): 217-21.
Mustonen J., Partanen J., Kanerva M., Pietilä K., Vapalahti O., Pasternack A., et al. Association of HLA B27 with benign clinical course of nephropathia epidemica caused by Puumala hantavirus. Scand. J. Immunol. 1998; 47(3): 277-9.

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HEMORRHAGIC FEVER WITH RENAL SYNDROME GROUP OUTBREAK CAUSED BY SOCHI VIRUS

Full Text

Abstract

Keywords

About the authors

References

Supplementary files

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