MOLECULAR EPIDEMIOLOGICAL ANALYSIS OF HIV INFECTION IN NORTHERN SEAPORTS OF RUSSIA

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Abstract

The results of the molecular-epidemiological analysis of HIV-1 variants circulating in Arkhangelsk and Murmansk - northern seaports of Russia - were presented. In these seaports the HIV-1 variants belonging to subtype A1 were predominant (93% in Murmansk, 83% in Arkhangelsk). In addition to these variants, viruses of other subtypes such as B, C, D and recombinant forms CRF02_AG and CRF03_AB were identified. The heterogeneity of circulating HIV-1 variants was higher in Arkhangelsk than in Murmansk. According to the results of phylogenetic analysis, subtype A1 sequences formed the common branch with nucleotide sequences of IDU-A strains found in other regions of Russia. HIV-1 variants of subtype B sub-clustered with sequences of East European B-variants. The recombinant strains CRF02_AG formed the common branch with HIV-1 sequences from Central Asia republics of the former USSR. Among 124 therapy-naive patients from Arkhangelsk and Murmansk (n = 124) the transmitted resistance was less than 5%.

About the authors

E. V. Kazennova

D.I. Ivanovsky Institute of Virology «Federal Research Center of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Author for correspondence.
Email: kazennova@rambler.ru
Russian Federation

V. Yu. Laga

D.I. Ivanovsky Institute of Virology «Federal Research Center of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

K. B. Gromov

D.I. Ivanovsky Institute of Virology «Federal Research Center of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

M. N. Sankov

D.I. Ivanovsky Institute of Virology «Federal Research Center of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

E. S. Popova

Arkhangelsk Clinical Center for Prevention and Control of AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

E. G. Lgumnova

Arkhangelsk Clinical Center for Prevention and Control of AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

E. N. Oparina

Arkhangelsk Clinical Center for Prevention and Control of AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

T. A. Sorokina

Arkhangelsk Clinical Center for Prevention and Control of AIDS and Infectious Diseases

Email: noemail@neicon.ru
Russian Federation

M. R. Bobkova

D.I. Ivanovsky Institute of Virology «Federal Research Center of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2017 Kazennova E.V., Laga V.Y., Gromov K.B., Sankov M.N., Popova E.S., Lgumnova E.G., Oparina E.N., Sorokina T.A., Bobkova M.R.

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