Прионные болезни человека и животных


Цитировать

Полный текст

Аннотация

В обзоре суммированы последние данные о молекулярных основах трансмиссивных
губксобразных энцефалопатии (ТГЭ), их этиологии, механизмах формирования прионных белков, штаммах, связанных с
ТГЭ, видовых барьерах для возникновения ТГЭ, патогенезе, диагностике и лечении ТГЭ.

Список литературы

  1. Alper Т., Cramp W. A., Haig D. A., Clarke M. С. Does the agent of scrapie replicate without nucleic acid // Nature. - 1967. - Vol. 214. - P. 764-764.
  2. Anderson R. M., Donnelly С. A., Ferguson N. M. et al. Transmission dynamic and epidemiology of BSE in British cattle // Nature. - 1996. - Vol. 382. - P. 779-788.
  3. Antoine N., Cesborn J. Y., Coumans B. et al. Differential expression of cellular prion protein on human blood and tonsil lymphocytes // Haematology. - 2000. - Vol. 85. - P. 475-480.
  4. Aucouturier P., Geissmann F., Damott D. et al. Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie // J. Clin. Invest. - 2001. - Vol. 108. - P. 703-708.
  5. Baron G. S., Wehrly K., Dorward D. V. et al. Conversion of raft associated prion protein the protease-resistant state requires insertion of PrP into continuous membranes// EMBO J. - 2002. -Vol.21. - P . 1031-1040.
  6. Bartz I. C., Kincaid A. E., Bessen R. A. Rapid prion neuroinvasion following tongue infection // J. Virol. - 2003. - Vol. 77. - P. 583-591.
  7. Bennion B. I., Daggett V. Protein conformation and diagnostic tests: the prion protein // Clin. Chem. - 2002. - Vol. 48. - P. 2105-2114.
  8. Bodemer W. The use of monoclonal antibodies in human prion disease // Naturwissenchaften. - 1999. - Bd 86. - S. 212- 220.
  9. Brown D. R., Hafiz F., Glassmith L. L. et al. Consequence of manganese replacement of Cu for prion protein function and proteinase resistance // EMBO J. - 2000. - Vol. 19. - P. 1180-1186.
  10. Brown D. R. Prion and prejudice normal protein and the synapse // Trends in Neurosc. - 2001. - Vol. 524. - P. 85-90.
  11. Brown D. Copper and prion disease // Brain Res. Bull. - 2000. - Vol. 55. - P. 165-173.
  12. Brown D. R., Hafiz F., Glassmith L. L. et al. Consequence of manganese replacement of copper for prion protein function and proteinase resistance // EMBO J. - 2000. - Vol. 19. - P. 1180-1186.
  13. Bueler H., Fisher M., Lang Y. et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein // Nature. - 1992. - Vol. 356. - P. 577-582.
  14. Caughy В., Chesebro B. Prion protein and the transmissible spongoform encephalopathies // Trend Cell Biol. - 1997. - Vol. 7. - P. 56-62.
  15. Chiarini L. В., Freitas A. R. O., Zanata S. M. et al. Cellular prior protein transduces new protective signal // EMBO J. - 2002. - Vol. 21. - P. 3317-3326.
  16. Chiesa R. P., Piccardo В., Chetti B. et al. Neurological illness in transgenic mice expressing a prior protein with an insertional mutation // Neuron. - 1998. - Vol. 21. - P. 1339-1351;
  17. Cohel G., Grigoriev V., Escaig-Haye F. et al. Ultrastructural localization of PPc at neuromuscular junction // J. Neurosci. Res. - 1999. - Vol. 55. - P. 261-267.
  18. Coitinho A. S., Roesler R., Martins V. R. et al. Cellular prion protein ablation impairs behavior as a function of age // Neuroreport. -2003. - Vol. 14. - P. 1375-1379.
  19. Collinge J. et al. Transmission of fatal familial insomnia to laboratory animals // Lancet. - 1995. - Vol. 346. - P. 569-570.
  20. DeArmond S. J., Prusiner S. B. Etiology and pathogenesis of prion diseases // Am. J. Pathol. - 1995. - Vol. 146. - P. 785- 811.
  21. Demaimay R., Adjou K., Lasmezas С. et al. Pharmacological studies of a new derivative of Amb. MS-8209 in mouse and humster scrapie // J. Gen. Virol. - 1994. - Vol. 75. - P. 2499-2503.
  22. Foumier I.-G., Escaig-Haye F., Grigoriev V. Ultrastructural localization of prion protein: physiological and pathological implications // Microsc. Res. Tech. - 2001. - Vol. 50. - P. 76- 88.
  23. Foumier I.-G. Nonneuronal cellular prion protein // Int. Rev. Cytol. - 2001. - Vol. 208. - P. 121-160.
  24. Foumier I.-G., Grigoriev V. B. Prion diseases: contribution of high resolution immune morphology // J. Cell Mol. Med. - 2001. - Vol. 5. - P. 367-377.
  25. Gambetti P., Parchi P., Peterson R. B. et al. Fatal familial insomnia and familial CJD: clinical, pathological and molecular feature // Brain Pathol. - 1995. - Vol. 5. - P. 43-51.
  26. Gauczynski S., Peyrin Y. M., Haik S. et al. The 37kDa/67kDa laminin receptor act as the cell-surface receptor for the cellular prion protein // EMBO J. - 2001. - Vol. 20. - P. 5863- 5875.
  27. Gibbs С J., Bolis С L. Normal isoform amyloid protein (PrP) in brain of spawning salmon // Mol. Psychiatry. - 1997. - Vol. 2. - P. 146-147.
  28. Giese A., Kretzchmar H. A. Prion-induced neuronal damage - the mechanisms of neuronal destruction in the subacute spongiform encephalopathies // Curr. Top. Microbiol. Immunol. - 2001. - Vol. 253. - P. 203-217.
  29. Glatzel M., Aguzzi A. Peripheral pathogenesis of prion disease // Microb. and Infect. - 2000. - Vol. 2. - P. 613-619.
  30. Glatzel M., Heppner F. L., Albers К. М. et al. Sympathetic innervation of lymphoreticular organs is rate-limited for prion neuroinvasion // Neuron. - 2001. - Vol. 31. - P. 25-34.
  31. Griffith J. S. Self-replication scrapie // Nature. - 1967. - Vol. 215. - P. 1043-1044.
  32. Grigoriev V. В., Adjou К. Т., Sales N. et al. Effect of the polyene antibiotic derivate MS-8209 on the astrocyte lysosomal system of scrapie-infected hamsters // J. Mol. Neurosci. - 2002. - Vol. 18. - P. 271-291.
  33. Grigoriev V. В., Escaig-Haye F., Streichenberger N. et al. Submicroscopic immunodetection of PrP in the brain of a patient with a new variant of Creutzfeld-Jakob disease // Neurosci. Lett. - 1999. - Vol. 263. - P. 59-63.
  34. Haeberle A., Rubaut-Barasson C., Bombarde G. et al. Synaptic prion protein immunoreactivity in the rodent cerebellum // Microsc. Res. Tech. - 2000. - Vol. 50. - P. 60-77.
  35. Harris D. A., Lele P., Snider W. D. Localization mRNA for a chicken prion protein by in situ hybridization // Proc. Natl. Acad. Sci. USA. - 1993. - Vol. 90. - P. 4309-4313.
  36. Harris D. Cellular biology of prion protein // Clin. Microbiol. Rev. - 1999. - Vol. 2. - P. 429-444.
  37. Heppner F. L., Musaht C., Arrighi I. et al. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies // Science. - 2001. - Vol. 294. - P . 178-182.
  38. Herms J., Tings Т., Gall S. et al. Evidence of presynaptic location and function of the prion protein // J. Neurosci. - 1999. - Vol. 19. - P. 8866-8875.
  39. Hill A. F, Zeidler M., Ironside J. et al. Diagnosis of nv CJD by tonsil biopsy // Lancet. - 1997. - Vol. 349. - P. 99.
  40. Hill A. F., Joines S., Linehan J. et al. Species-barrier-independent prion replication in apparently resistant species // Proc. Natl. Acad. Sci. USA. - 2000. - Vol. 97. - P. 10248-10253.
  41. Horiuchi M., Priola S. A., Chabry J. et al. Interaction between heterologous form of prion protein. Binding, inhibition of conversion, and species barries // Proc. Natl. Acad. Sci. USA. - 2000. - Vol. 97. - P. 5836-5841.
  42. Ironside I. W., Head M. W. Variant CID disease and its transmission by blood // J. Thrombos. Haemostas. - 2003. - Vol. 1. - P. 1479-1486.
  43. Jackson G. S., Callinge J. The molecular pathology CJD: old and new variants // J. Clin. Pathol. - 2001. - Vol. 54. - P. 393-399.
  44. Klohn P. C, Stoltze L., FlechsigE. et al. A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions // Proc. Natl. Acad. Sci. USA. - 2003. - Vol. 100. - P. 11666-11671.
  45. Korth C., May B. С. H., Cohen F. E. et al. Acridin and phenothiazin derivates as pharmatherapeutics for prion diseases // Proc. Natl. Acad. Sci. USA. - 2001. - Vol. 98. - P. 9836-9841.
  46. Korth C., Stierli В., Streit P. et al./ Prion (PrPsc) - specific epitope defined by a monoclonal antibody // Nature. - 1997. - Vol. 390. - P. 74-77.
  47. Kretzchmar H. A., Stowring L. E., Westway D. et al. Molecular cloning of a human prion protein cDNA // DNA. - 1986. - Vol. 5. - P. 315-324.
  48. Kuzuhara S., Kanazawa I., Sasaki H. et al. GSS disease // Ann. Neurol. - 1983. - Vol. 140. - P. 1411-1420
  49. Lasmezas C., Deslys J.-P., Robain O. et al. Transmission of the BSE to mice in the absence detectable abnormal prion protein // Science. - 1997. - Vol. 275. - P. 402-405.
  50. Lin Т., Li R., Pan T. et al. Intercellular transfer of the cellular prion protein // J. Biol. Chem. - 2002. - Vol. 277. - P. 47671-47678.
  51. Lotscher M., Recher M., Hunriker L. et al. Immunologically induced complement-dependent up-reulation of the prion protein in the mouse spleen: follicular dendritic cells versus capsule and trabeculae // J. Immunol. - 2003. - Vol. 170. - P. 6040- 6047.
  52. Mange A., Nishida N., Milhavet O. et al. Amb inhibits the generation of the scrapie isoform of the prion protein in infected cultures // J. Virol. - 2000. - Vol. 74. - P. 3135-3140.
  53. McBride P. A., Eikelenboom P., Kraal G. et al. PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie infected mice // J. Pathol. - 1992. - Vol. 168. - P. 413-418.
  54. McBride P. A., Beekes M. Pathological PrP is abundant in sympathic and sensory ganglia of hamsters fed with scrapie // Neurosci. Lett. - 1999. - Vol. 265. - P. 135-138.
  55. Mehlhom I., Groth D., Stochel J. et al. High level expression and characterization of purified 142-residue polypeptide of the prion protein // Biochemistry. - 1996. - Vol. 35. - P. 5528-5537.
  56. Miele G., Jeffrey M., Tumbull D. et al. Ablation of cellular prion protein expression affect mitohondrial number and morphology // Biochem. Biophys. Res. Commun. - 2002. - Vol. 291. - P. 372-377.
  57. Miele G., Manson I., Clinton M. A. A novel erythroid-specific marker of TSE // Nature Med. - 2001. - Vol. 7. - P. 361- 364.
  58. Mondjou M., Flobert Y., Grassi J. et al. Cellular prion protein status in sheep: tissue-specific biochemical signature // J. Gen. Virol. - 2001. - Vol. 82. - P. 2017-2024.
  59. Montrasio F., Frigg R., Glatzel M. et al. Impaired prion replication in spleen of mice lacking functional follicular dendritic cells // Science. - 2000. - Vol. 288. - P. 1257-1259.
  60. Moore R. C., Lee J. J., Silverman G. L. et al. Ataxia in PrP-deficient mice is associated with upregulation of the novel PrPlike protein Doppel // J. Mol. Biol. - 1999. - Vol. 292. - P. 797-817.
  61. Muniz M., Riezman H. Intracellular transport of GPI-anchored proteins // EMBO J. - 2000. - Vol. 19. - P. 10-15.
  62. Palmer M. S., Dryden A. J, Hughes J. T. etal. Homozygous prion protein genotype predisposes to sporadic CJD // Nature. - 1991. - Vol. 352. - P. 340-342.
  63. Pammer J., Suchy A., Rendi M. et al. Cellular prion protein expressed by bovine squamous epithelia of skin and upper gastrointestinal tract // Lancet. - 1999. - Vol. 359. - P. 1702- 1703.
  64. Pan K.-M., Baldwin M., Nguen J. et al. Conversion of a-helices into p-sheets features in the formation of the scrapie prion protein // Proc. Natl. Acad. Sci. USA. - 1993. - Vol. 90. - P. 10962-10966.
  65. Parchi P., Gambetti P. Human prion diseases // Curr. Opin. Neurol. - 1995. - Vol. 8. - P. 286-293.
  66. Parchi P., Zon W., Wang W. et al. Genetic influence on the structural variation of the abnormal prion protein // Proc. Natl. Acad. Sci. USA. - 2000. - Vol. 97. - P. 10168-10172.
  67. Pauly P., Harris D. A. Copper stimulates endocytosis of the prion protein // J. Biol. Chem. - 1998. - Vol. 73. - P. 33107- 33110.
  68. Petersen R. В., Parchi P., Richardson S. et al. Effect of the DI78N mutation and the codon 129 polymorphism of the prion protein // J. Biol. Chem. - 1996. - Vol. 271. - P. 12661- 12668.
  69. Prinz M., Montrasio F., Klein M. A. et al. Lymphnodal prion replication and neuroinvasion in mices devoid of FDC // Proc. Natl. Acad. Sci. USA. - 2002. - Vol. 99. - P. 919-924.
  70. Priola S. A. Prion portein diversity and disease in the TSE // Adv. Protein Chem. - 2001. - Vol. 57. - P. 1-27.
  71. Prusiner S. Prions // Proc. Natl. Acad. Sci. USA. - 1998. - Vol. 95. - P. 13363-13383.
  72. Prusiner S. B. Novel proteinaceous infectious particles cause scrapie // Science. - 1982. - Vol. 216. - P. 136-144.
  73. Prusiner S. B. The prion diseases // Brain Pathol. - 1998. - Vol. 8. - P. 499-513.
  74. Prusiner S. B. Molecular biology of prion diseases // Science. - 1991. - Vol. 252. - P. 1515-1522.
  75. Purdey M. Ecosystems supporting clusters of sporadic TSEs demonstrate excess of the radical-generating divalent cation manganese and deficiencies of antioxidant cofactors Cu, Se, Fe, Zn // Med. Hypothes. - 2000. - Vol. 54. - P. 278-306.
  76. Quaglio E., Chiesa R., Harris D. A. et al. Copper convert the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform // J. Biol. Chem. - 2001. - Vol. 276. - P. 11432.
  77. Race R., Meade-White K., Raines A. et al. Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages // J. Infect. Dis. - 2002. - Vol. 186. - Suppl. 2. - P. S166-S170.
  78. Rachidi W., Mange A., Senator A. et al. Prion infection impairs copper binding of culture cells // J. Biol. Chem. - 2003. - Vol. 278. - P. 14595-14598.
  79. Riek R., Hornemann S., Glockshuber R. et al. NMR characterization on the full-length recombinant murine prion // FEBS Lett. - 1997. - Vol. 413. - P. 282-288.
  80. Riesner D., Kelling K., Post K. et al. Disruption of prion rods generated 10 nm spherical particles having high a-helical content and lacking scrapie infectivity // J. Virol. - 1996. - Vol. 70. - P. 1714.
  81. Rossi G., Salmona M., Forloni G. et al. Therapeutic approaches to prion diseases // Clin. Lab. Med. - 2003. - Vol. 23. - P. 187-208.
  82. Rudd P. M., Wormald M. R., Wing D. R. et al. Prion glycoprotein: structure, dynamics and roles for the sugars // Biochemistry. - 2001. - Vol. 40. - P. 3761-3766.
  83. Saborio P., Permanne В., Soto С. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding // Nature. - 2001. - Vol. 411. - P. 810-813.
  84. Safar J., Cohen F. E., Prusiner S. B. Quantitative traits of prion strains are unciphered in the conformation of the prion protein // Arch. Virol. - 2000. - Vol. 16. - Suppl. - P. 227-235.
  85. Shaked G. M., Shaked Y., Kariv-Inbal Z. et al. A protease-resistant prion protein isoform is present in urine of animals and humans affected with prion diseases // J. Biol. Chem. - 2001. - Vol. 276. - P. 34479-34482.
  86. Shaked Y., Rosenmann H., Talmor G., Gabizon R. Terminal trunkated PrP isoform is present in mature sperm // J. Biol. Chem. - 1999. - Vol. 274. - P. 2153-2158.
  87. Simonie Т., Duga S., Strumbo B. et al. cDNA cloning of turtle prion protein // FEBS Lett. - 2000. - Vol. 469. - P. 33-38.
  88. Soto C., Kascsak R. I., Saborio G. P. et al. Reversion of prion protein conformational changes by synthetic |3-sheet breaker peptide // Lancet. - 2000. - Vol. 355. - P. 192-197.
  89. Tobler L., Deboer Т., Fisher M. P. et al. Sleep and sleep regulation in normal and prion-deficient mice // J. Neurosci. - 1997. - Vol. 17. - P. 1869-1879.
  90. Van Rheede T. Smolenaars M. M., Madsen O. et al. Molecular evolution of the mammalian prion protein // Mol. Biol. Evol. - 2003. - Vol. 20. - P. 11-121.
  91. Viles J. H., Cohen F. E., Prusiner S. B. et al. Copper binding to the prion protein. Structural implications of four identical copper- active binding sites // Proc. Natl. Acad. Sci. USA. - 1999. - Vol. 96. - P. 2042-2047.
  92. Walmsley A. R., Zeng F., Hooper N. M. The N-terminal region of the prion protein ectodomain contain a lipid raft targeting determinant // J. Biol. Chem. - 2003. - Vol. 278. - P. 37241-37248.
  93. Wechselberger C., Wurm S., Pfarr W. et al. The physiological function of prion protein // Exp. Cell Res. - 2002. - Vol. 281. - P. 1-8.
  94. Will R. G., Ironside Y. W., Zeidler M. et al. A new variant of Creutzfeldt-Jakob disease in the UK // Lancet. - 1996. - Vol. 347. - P. 921-925.
  95. Wong B. S., Chen S. G., Colucci M. et al. Abberrant metal binding by prion protein in human prion disease // J. Neurochem. - 2001. - Vol. 78. - P. 1400-1408.
  96. Wu Q., Wang Y., Wang I. et al. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissue// J. Exp. Med. - 1999. - Vol. 190. - P. 629-638.
  97. Wuthrich K., Riek R. Three dimensional structures of prion protein // Adv. Protein Chem. - 2001. - Vol. 57. - P. 55-82.
  98. Zeidler M., Ironside I. W. The new variant of CID // Rev. Sci. Tech. - 2001. - Vol. 19. - P. 98-120.
  99. Zou W. Q., Capellari S., Parchi P. Identification of novel proteinase K-resistant C-terminal fragments of PrP in CJD // J. Biol. Chem. - 2003. - Vol. 278. - P. 40429-40436.

Дополнительные файлы

Доп. файлы
Действие
1. JATS XML
Скачать

© Григорьев В.Б., 2004

Creative Commons License
Эта статья доступна по лицензии Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-77676 от 29.01.2020.


Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах