Преимущества и недостатки инактивированной и живой вакциныпротив гриппа


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Аннотация

Приведен анализ данных литературы, касающихся сравнения безопасности, эффективности и некоторых
других свойств холодоадаптированной живой гриппозной вакцины (ХЖГВ) и инактивированной гриппозной вакцины (ИГВ). ИГВ и ХЖГВ не различаются по системным реакциям после введения препарата, но не
исключена потенциальная возможность неблагоприятных реакций при вакцинации лиц с аллергией к белкам куриных эмбрионов, а также персистенции/реверсии холодоадаптированных штаммов при вакцинации лиц с первичными нарушениями иммунной системы. До настоящего времени нет убедительных данных о том, что при борьбе с пандемиями гриппа ХЖГВ имеет преимущество перед ИГВ. Необходимы дoполнительные контролируемые полевые сравнительные исследования эффективности ИГВ и ХЖГВ при
иммунизации пожилых лиц. Получены ограниченные данные о безвредности и иммуногенности ХЖГВ для
детей в возрасте от 2 мес. Определенным недостатком ХЖГВ является необходимость двукратной вакцинации лиц всех возрастных групп для получения хорошего иммунного ответа ко всем трем компонентам
ХЖГВ. При применении ИГВ двукратная вакцинация рекомендуется только для лиц, не болевших гриппом.
Интраназальное введение ХЖГВ с практической и психологической точки зрения имеет преимущество перед введением ИГВ с помощью шприца. Преимуществом ХЖГВ перед ИГВ может оказаться способность
этого препарата защищать от дрейфовых вариантов вируса гриппа, хотя необходимы дальнейшие исследования. Оптимальным субстратом для производства ИГВ и ХЖГВ могут быть перевиваемые линии клеток, удовлетворяющие требованиям ВОЗ. Оптимальной возрастной группой для профилактики гриппа с
помощью ХЖГВ являются дети, в то время как ИГВ более подходит для вакцинации взрослых и пожилых
лиц.

Список литературы

  1. Wright P., Karzon D. Live attenuated influenza vaccines // Progr. Med. Virol. - 1987. - Vol. 34. - P. 70-88.
  2. Wright P., Ghendon Y., Clements M. et al. Vaccines for pandemic situation//J. Infect. Dis. - 1997. - Vol. 176. - Suppl. I. - P. S80-S82.
  3. Tamblin S., Hinman A. Pandemic planning: conclusion and recommendation/ Eds A. Kendal et al. - Amsterdam, 1993. - P. 457-459.
  4. Александрова Г., Климов А. Живая гриппозная вакцина. - СПб, 1994.
  5. Ghendon Y. Influenza vaccines: a main problem in control of pandemic // Eur. J. Epidemiol. - 1994. - Vol. 10. - P. 485- 486.
  6. Ghendon Y. Cold-adapted live influenza vaccines developed in Russia // Textbook of Influenza / Eds K. Nicholson et al. - Oxford, 1998. - P. 391-399.
  7. Kendal A. Cold adapted live attenuated vaccines developed in Russia: can they contribute to meeting the needs for influenza control in other countries? // Eur. J. Epidemiol. - 1997. - Vol. 13. - P. 591-609.
  8. Keited W., Piedra P. Live cold-adapted, reassortant influenza vaccines // Textbook of Influenza / Eds K. Nicholson et al. - Oxford, 1998. - P. 373-390.
  9. Rudenko L., Alexandrova G. Current strategies for the prevention of influenza by Russian cold-adapted live influenza vaccine among different populations // Options for the Control of InfluenzaIV / Eds A. Osterhaus et al. - Amsterdam, 2001. - P. 945-950.
  10. Beyer W., Palach A., de Jong J., Osterhaus A. Cold-adapted live influenza vaccine versus inactivated vaccine: systemic vaccine reaction, local and systemic antibody response, and vaccine efficacy. A meta-analysis // Vaccine. - 2002. - Vol. 20. - P.1340-1353.
  11. Slepushkin A., Obrosova-Serova N., Burtseva E. et al. Comparison of live attenuated and inactivated vaccines in schoolchildren in Russia: I. Safety and efficacy in two Moscow schools, 1987/88 // Vaccine. - 1993. - Vol. 11. - P. 323-328.
  12. Rudenko L., Slepushkin A., Monto A. et al. Efficacy of live attenuated and inactivated influenza vaccines in schoolchildren and their unvaccinated contacts in Novgorod, Russia // J. Infect. Dis. - 1993. - Vol. 168. - P. 881-887.
  13. Rudenko L., Lonskaya N., Klimov A. et al. Clinical and epidemiological evaluation of a live, cold-adapted influenza vaccines for 3-14 years olds // Bull. Wld Hlth Org. - 1996. - Vol. 74. - P. 77-84. 10
  14. James J., Zeiger R., Lester M. Safe administration of influenza vaccine to patients with egg allergy // J. Pediatr. - 1998. - Vol. 133. - P. 624-628.
  15. Waters Т., Beeb J., Miller W. Yellow fever vaccination, avian leucosis and cancer risk in man // Science. - 1972. - Vol. 177. - P. 76-77.
  16. Petricciani J. Regulatory philosophy and acceptability of cells for production of biologicals // Dev. Biol. Stand. - 1991. - Vol. 75. - P. 9-15.
  17. Гендон Ю., Маркушин С, Акопова И. и др. Разработка культуральной живой холодоадаптированной реассортантной гриппозной вакцины // Вопр. вирусол. - 2003. - № 2. - С. 12-17.
  18. Carbone М., Rizzo P., Pass H. Simian virus, poliovaccines and human cancers: a review of recent development // Oncogene. - 1997. - Vol. 15. - P. 1877-1888.
  19. Pizzo P., Resta I., Powers A. et al. Unique strains of SV40 in commercial poliovaccines from 1955 not readily identifable with current testing for SV40 infection // Cancer Res. - 1999. - Vol. 56. - P. 6103-6108.
  20. Requirements for influenza vaccine (live) // WHO Techn. Rep. Ser. - 1979. - N 638.
  21. Robertson J., Nicolson C., Newman R. et al. High grow reassortant influenza vaccine virus: new approaches to their control / / Biologicals. - 1992. - Vol. 20. - P. 213-220.
  22. Wyatt H. Poliomyelitis in hypogammaglobulinemies // J. Infect. Dis. - 1973. - Vol. 151. - P. 802-806.
  23. Wood D., Sutter R., Dowdle W. Stopping poliovirus vaccination after eradication: issue and challenge // Bull. Wld Hlth Org. - 2000. - Vol. 78. - P. 347-357.
  24. Sutter R., Prevots D. Vaccine-associated paralytic poliomyelitis among immunologically abnormal persons // Infect, in Med. - 1994. - Vol. 11. - P. 426-430; 435-438.
  25. Kew O., Sutter R., Nottay B. et al. Prolonged replication of type 1 vaccine-derived poliovirus in an immunodeficient patient //J. Clin. Microbiol. - 1998. - Vol. 36. - P. 2893-2899.
  26. Belmunt A. Evolution of poliovirus type 1 during 5,5 years of prolonged enteral replication in an immunodeficient patient // Virology. - 1999. - Vol. 265. - P. 178-184.
  27. Martin J., Dunn G., Hull R. et al. Evolution of the Sabin strain of type 3 poliovirus in an immunodeficient patient during the entire 637-day period of virus excretion // J. Virol. - 2000. - Vol. 74. - P. 3001-3010.
  28. Rosen F., Cooper M., Wedgwood R. The primary immunodeficiencies// N. Engl. J. Med. - 1995. - Vol. 333. - P. 431- 440.
  29. Evanx K., Kline M. Prolonged influenza A infection responsive to rimantadine therapy in a human immunodeficiency virus-infected child // Pediatr. Infect. Dis. J. - 1995. - Vol. 14. - P. 332-334.
  30. Klimov A., Rocha E., Hagden F. et al. Prolonged shedding of amantadin-resistant influenza A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis// J. Infect. Dis. - 1995. - Vol. 172. - P. 1352-1355.
  31. King J., TreanorJ., Fast P. et al. Comparison of the safety, vaccine virus shedding, and immunogenicity of influenza virus vaccine, trivalent, types A and B, live cold-adapted, administered to human immunodeficiency virus (HIV)-infected and non- HIV infected adults // J. Infect. Dis. - 2000. - Vol. 181. - P. 725-728.
  32. King J., Fast P., Zangwill K. et al. Safety, vaccine virus shedding and immunogenicity of trivalent, cold-adapted, live attenuated influenza vaccine administered to human immunodeficiency virus- infected and noninfected children // Pediatr. Infect. Dis. J. - 2001. - Vol. 20. - P. 1124-1131.
  33. Cha Т., Kao K., Zhan J. et al. Genotypic stability of cold-adapted influenza virus vaccine in an efficacy clinical trial // J. Clin. Microbiol. - 2000. - Vol. 38. - P. 839-845.
  34. Cox N., Kendal A. Genetic stability of A/AnnArbor/6/60 coldmutant (ts) live influenza virus genes: analysis by oligonucleotide mapping of recombinant vaccine strains before and after replication in volunteers // J. Infect. Dis. - 1984. - Vol. 149. - P. 194-200.
  35. Медведева Т., Романова Ю., Гущина М. и др. Тс-фенотип реозолятов от детей, вакцинированных живой холодоадаптированной гриппозной вакциной типа А // Вопр. вирусол. - 1990. - Т. 35. - С. 101-105.
  36. Tolpin M., Massicot Т., Mullinix J. et al. Genetic factors associated with loss of the ts phenotype of the influenza A/Alaska/ 77-ts-l A2 recombinant during growth in vivo // Virology. - 1981. - Vol. 112. - P. 505-517.
  37. Ghendon Y., Markushin S., Lisovskaya K. et al. Extragenic suppression of a ts phenotype during recombination between ts mutants of two fowl plague virus strains with a ts mutation in gene1 // J. Gen. Virol. - 1982. - Vol. 62. - P. 239-248.
  38. Pfleiderer M., Lower J., Kurth R. Cold-adapted live influenza vaccines, a risk-benefit assessment // Vaccine. - 2002. - Vol. 20. - P. 886-894.
  39. Edwards K., Dupont W., Westrich M. et al. A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease // J. Infect. Dis. - 1994. - Vol. 196. - P. 68-70.
  40. Yamane N., Veda K., Kimura M. A large-scale field trial of trivalent cold-adapted influenza virus live vaccine in Japan // Options for the Control of Influenza III / Eds L. Brown et al. - Amsterdam, 1996. - P. 628-633.
  41. Nichol K., Margolis K., Wuorenma J., Von Sternberg T. The efficacy and cost effectiveness of vaccination against influenza among elderly people living in the community // N. Engl. J. Med. - 1994. - Vol. 331. - P. 778-784.
  42. Lee M., Yang С. Cross-reactive HlNl antibody response to a live attenuated influenza vaccine in children: implication for selection of vaccine strains // J. Infect. Dis. - 2003. - Vol. 188. - P. 1362-1366.
  43. Nichol K. Efficacy/clinical effectiveness of inactivated influenza vaccines in adults // Textbook of Influenza / Eds K. Nicholson et al. - Oxford, 1998. - P. 358-372.
  44. Couch R., Keitel A., Cate T. et al. Prevention of influenza virus infection by current inactivated influenza vaccines // Options for the Control of Influenza III / Eds L. Brown et al. - Amsterdam, 1996. - P. 97-106.
  45. Bridges C., Thompson W., Meltzer M. et al. Effectiveness and cost-benefit of influenza vaccination of healthy working adults. A randomized control trial // J. A. M. A. - 2000. - Vol. 284. - P. 1655-1663.
  46. JianpingH., Xin F., Changshun L. et al. Assessment of effectiveness of Vaxigrip // Vaccine. - 1999. - Vol. 17. - P. S57-S58.
  47. Piedra P., Glezen W. Influenza in children: epidemiology, immunity, and vaccines //Sem. Pediatr. Infect. Dis. - 1991. - Vol. 2. - P. 140-146.
  48. Clover R., Cranford S., Glezen W. et al. Comparison of heterotypic protection against influenza A/Taiwan/86 (HlNl) by attenuated and inactivated vaccines to A/Chile/83 like virus // J. Infect. Dis. - 1991. - Vol. 163. - P. 300-304.
  49. Wright P., Cherry J., Foy H. et al. Antigenicity and reactogenicity of influenza A/USSR/77 virus vaccine in children: a multicentered evaluation of a dosage and safety // Rev. Infect. Dis. - 1983. - Vol. 5. - P. 758-764.
  50. Gruber W., Taber L., Glezen W. et al. Live attenuated and inactivated influenza vaccines in schoolage children // Am. J. Dis. Child. - 1990. - Vol. 144. - P. 595-600.
  51. Belshe R., Mendelman P., Treanor J. et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine in children // N. Engl. J. Med. - 1998. - Vol. 338. - P. 1405-1412.
  52. Heikkinen Т., Puuskanen O., Waris M. et al. Influenza vaccination in the prevention of acute otitis media in children // Am.J. Dis. Child. - 1999. - Vol. 145. - P. 445-448.
  53. Clements D., Langdon L., Bland C., Walter E. Influenza A vaccine decreases the incidence of otitis media in 6 to 30-monthold children in day care // Arch. Pediatr. Adolesc. Med. - 1995. -Vol. 149.- P. 1113-1117.
  54. Belshe R., Gruber W. Prevention of otitis media in children with live attenuated vaccine given intranasally // Pediatr. Infect. Dis. J. - 2000. - Vol. 19. - P. 566-571.
  55. Izurieta H., Thompson W., Kramarz P. et al. Influenza and the rate of hospitalization for respiratory disease among infants and young children // N. Engl. J. Med. - 2000. - Vol. 342. - P. 232-239
  56. Neuzil K., Mellen В., Wright P. et al. The effect of influenza on hospitalization, outpatient visit, and courses of antibiotics in children // N. Engl. J. Med. - 2000. - Vol. 342. - P. 225- 231.
  57. Neuzil K., Zhu Y., Griffin M. et al. Burden of interpandemic influenza in children younger than 5 years: a 25-years prospective study // J. Infect. Dis. - 2002. - Vol. 185. - P. 147-152.
  58. Belshe R. Efficacy and effectiveness of attenuated, cold-adapted, trivalent intranasal influenza vaccine // Option for the Control of Influenza IV / Eds A. Osterhaus et al. - Amsterdam, 2001. - P. 931-937.
  59. Belshe R., Swierkosz E., Anderson E. et al. Immunization of infant and young children with live attenuated trivalent cold-recombinant influenza A/H1N1, H3N2 and В vaccine // J. Infect. Dis. - 1992. - Vol. 16. - P. 727-732.
  60. Swierkosz E., Newman F., Anderson E. et al. Multidose live attenuated, cold-recombinant, trivalent influenza vaccine in infants and young children // J. Infect. Dis. - 1994. - Vol. 169. - P. 1121-1124.
  61. Karzon R., Steinhoffff M., Subbarao E. et al. Safety and immunogenicity of a cold-adapted influenza A (HlNl) reassortant virus vaccine administered to infant less than 6 month of age // Pediatr. Infect. Dis. J. - 1995. - Vol. 14. - P. 10-16.
  62. Gruber W., Belshe R., King G. et al. Evaluation of live attenuated influenza vaccines in children 6-18 month of age: safety, immunogenicity, and efficacy // J. Infect. Dis. - 1996. - Vol. 173. - P. 1313-1319.
  63. Gruber W., Darden P., Still J. et al. Evaluation of bivalent live attenuated influenza A vaccines in children 2 month to 3 years of age: safety, immunogenicity and dose-response // Vaccine. - 1997. - Vol. 15. - P. 1379-1384.
  64. Clements M., Tierney E., Murphy B. Response of seronegative and seropositive adult volunteers to live attenuated cold-adapted reassortant influenza A virus vaccine // J. Clin. Microbiol. - 1985. - Vol. 21. - P. 997-999.
  65. Couch R., Quarles J., Cate T, Zahradnik J. Clinical trials with cold-reassortant influenza virus vaccine // Options for the Control of Influenza / Eds A. Kendal, P. Patriarka. - New York, 1986. - P. 223-241.
  66. Couch R. Advances in influenza virus research // Ann. N. Y. Acad. Sci. - 1993. - Vol. 685. - P. 803-812.
  67. Treanor J., KotloffK., Betts R. et al. Evaluation of trivalent, live, cold-adapted and inactivated influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2) and В viruses // Vaccine. - 2000. - Vol. 18. - P. 899-906.
  68. Nichol K., Mendelman P., Mallon K. et al. Effectiveness live attenuated intranasal influenza virus vaccine in healthy, working adults. A randomized controlled trials // J. A. M. A. - 1999. -Vol.282. - P . 137-144.
  69. Powers D., Fries L., Murphy B. et al. In elderly person live attenuated influenza A virus vaccine do not offer an advantage over inactivated virus vaccine in inducing serum secretory antibodies or local immunologic memory // J. Clin. Microbiol. - 1991. - Vol. 29. - P. 498-505.
  70. Treanor J., Dumyati G., O'Brien D. et al. Evaluation of coldadapted, reassortant influenza В virus vaccine in elderly and chronically ill adults // J. Infect. Dis. - 1994. - Vol. 169. - P. 402-407.
  71. Treanor J., Mattison H., Dumyati G. et al. Protective efficacy of combined live intranasal and inactivated influenza A virus vaccines in the elderly // Ann. Intern. Med. - 1992. - Vol. 117. - P. 625-633.
  72. Treanor J., Betts R. Evaluation of live cold-adapted influenza A and В virus vaccines in elderly and high-risk subjects // Vaccine. - 1998. - Vol. 16. - P. 1756-1760.
  73. Rudenko L., Arden N., Grigorieva E. et al. Immunogenicity and efficacy of Russian live attenuated and US inactivated influenza vaccines used alone and in combination in nursing home residence // Vaccine. - 2001. - Vol. 19. - P. 308-318.
  74. Wiselka M. Vaccine safety // Textbook of Influenza / Eds K. Nicholson et al. - Oxford, 1998. - P. 346-357.
  75. Couch R., Kasel J. Immunity to influenza to man // Ann. Rev. Microbiol. - 1983. - Vol. 37. - P. 529-549.
  76. Boyce Т., Gruber W., Coleman-Dockery S. et al. Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in children // Vaccine. - 1999. - Vol. 18. - P. 82- 88.
  77. Gluck U., Gebbers J., Gluk R. Phase I evaluation of intranasal virosomal influenza vaccine with and without E. coli heat-label toxin in adult volunteers // J. Virol. - 1999. - Vol. 73. - P. 7780-7786.
  78. Гендон Ю. 3. Разработка инактивированных мукозальных гриппозных вакцин // Журн. микробиол. - 2003. - № 4. - С . 110-117.
  79. De Jong J., Beyer W., Palache A. et al. Mismatch between the 1997/1998 influenza vaccine and the major epidemic A(H3N2) virus strain as the cause of an inadequate vaccine-induced antibody response to this strain in the elderly // J. Med. Virol. - 2000. - Vol. 61. - P. 94-99.
  80. Belshe R., Gruber W., Mendelman P. et al. Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine // J. Pediatr. - 2000. - Vol. 136. - P. 168- 175.
  81. Longini I., Harroran M., Nizan A. et al. Estimation of the efficacy of live, attenuated influenza vaccine from two-year, multicenter vaccine trial: implication for influenza epidemic control // Vaccine. - 2000. - Vol. 18. - P. 1902-1909.
  82. Alexandrova G., Polezhaev F., Budilovsky G. et al. Recombinant cold-adapted attenuated influenza A vaccines for use in children: reactogenicity and antigenic activity of cold-adapted recombinants and analysis of isolates from vaccines // Infect, and Immun. - 1984. - Vol. 44. - P. 734-739.
  83. Khan A., Polezfiaev F., Vasilieva R. et al. Comparison of US inactivated split-virus and Russian live attenuated, cold-adapted trivalent influenza vaccines in Russian schoolchildren // J. Infect. Dis. - 1996. - Vol. 173. - P. 453-456.
  84. Potter C., Jennings R., Clark A., Ali M. Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers // J. Med. Virol. - 1983. - Vol. 11. - P. 77-86.
  85. Romanova J., Ermachenko Т., Alexandrova G., Tannock G. Interference between cold-adapted (ca) influenza A and В vaccine reassortant or between ca reassortant and wild-type strains in eggs and mice // Vaccine. - 1994. - Vol. 12. - P. 23-27.
  86. Piedra P., Glezen W., Mbawuike I. et al. Studies on reactogenicity and immunogenicity of attenuated bivalent cold recombinant influenza virus vaccines in type A and inactivated trivalent influenza virus vaccines in infants and young children // Vaccine. - 1993. - Vol. 11. - P. 718-724.
  87. Gruber W., Kirschner K., Tollefson S. et al. Comparison of monovalent and trivalent live attenuated influenza vaccines in young children // J. Infect. Dis. - 1993. - Vol. 168. - P. 5 3 - 60.
  88. Gruber W. Factors important in ensuring iummunogenicity of multivalent ca influenza vaccine in young children // Options in the Control of Influenza III / Eds L. Brown et al. - Amsterdam, 1996. - P. 622-627.
  89. Gruber W. Children as a target for immunization // Textbook of Influenza / Eds K. Nicholson et al. - Oxford, 1998. - P. 435-444.
  90. Clements M., Makhene M., Karron E. et al. Effective immunization with live attenuated influenza A virus can be achieved in early infancy // J. Infect. Dis. - 1996. - Vol. 173. - P. 44- 51.
  91. Masurel N., Laufer J. A one-year study of trivalent influenza vaccine in primed and unprimed volunteers: immunogenicity, clinical reactions and protection // J. Hyg. - 1984. - Vol. 92. - P. 263-266.
  92. Powers D., Murphy В., Fries M. et al. Reduced infectivity of cold-adapted influenza A/H1N1 viruses in the elderly: correlation with serum and local antibodies // J. Am. Geriatr. Soc. - 1992. - Vol. 40. - P. 163-167.
  93. Fox J., Elveback L. Herd immunity: changing concepts // ViralImmunology and Immunopathology / Ed. A. Notkins. - New York, 1975. - P. 273-290.
  94. Monto A., Davenport F., Napier J., Francis T. Modification of an outbreak of influenza in Tecumseh, Michigan by vaccination of schoolchildren // J. Infect. Dis. - 1970. - Vol. 122. - P. 16-25.
  95. Warburg M., Jacobs D., Langsford W., White G. Herd immunity following influenza vaccine administration // Med. J. Aust. - 1972. - Vol. 2. - P. 67-70.
  96. Potter J., Scott D., Roberts M. Influenza vaccination of health care workers in long-term care hospital reduces the mortality of elderly patients // J. Infect. Dis. - 1997. - Vol. 175. - P. 1- 6.
  97. Arden N., Monto A., Ohmit S. Vaccine use and the risk of outbreaks in a sample of nursing homes during an influenza outbreak// Am. J. Publ. Hlth. - 1995. - Vol. 85. - P. 399-401.
  98. Brands R., Visser J., Medema J. et al. Influvac Тс. a safe Madin Darby canine kidney (MDCK) cell culture-base influenza vaccine // Dev. Biol. Stand. - 1999. - Vol. 98. - P. 93-100.
  99. Kistner O., Barrett P., Mundt W. et al. A novel mammalian cell (Vero) derived influenza vaccine: development, characterization and industrial scale production // Wien. Klin. Wschr. - 1999. - B d 111. - S . 207-214.

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