COMPARATIVE ANALYSIS OF SEROLOGICAL MARKERS OF HERPES VIRUSES AND QUANTITATIVE IMMUNOGLOBULINOPATHIES IN PRIMARY PATIENTS WITH ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA

Cover Page


Cite item

Full Text

Abstract

Introduction. Angioimmunoblastic T-cell lymphoma (AITL) is associated with the Epstein-Barr virus (EBV) in most cases. It is believed polyclonal hypergammaglobulinaemia observed in 53-80% of AITL patients has anti-herpes viral antibodies as its substrate. Aim. The aim of the study was to compare serological markers of herpes viruses and quantitative immunoglobulinopathies of classes M and G in primary patients with AITL. Materials and methods. 26 primary patients with newly diagnosed AITL treated at the National Research Center for Hematology from 2002 to 2017 were enrolled in the study. The male/female ratio was 16/10; median age was 62 (29-81) years. The levels of total immunoglobulins of classes M and G, serological markers of EBV, cytomegalovirus (CMV) and herpes simplex virus type 1 and type 2 (HSV 1, 2) were assessed in all patients. Results. Significant relationship was found between the presence of virus-specific IgM (IgM HSV 1, 2, IgM CMV, IgM VCA EBV) and an elevated level of total immunoglobulins of class M (p <0.0001). Studies of each virus separately showed that the greatest correlation was observed for IgM HSV 1, 2 (p <0,0001), whereas the association of IgM CMV and IgM VCA EBV with quantitative immunoglobulinopathies of class M was not confirmed (p = 0,15 and p = 0,36 respectively). There was no considerable relationship between polyclonal IgG hypergammaglobulinaemia and an increased level of antiviral IgG (IgG HSV 1, 2, IgG CMV, IgG EBNA-1 EBV, IgG EA EBV) (p> 0,37). Conclusion. We have shown that the presence of the anti-herpes viral IgM strictly correlates with polyclonal IgM hypergammaglobulinaemia, while an increased level of virus-specific IgG antibodies does not affect the formation of polyclonal IgG hypergammaglobulinaemia and can be observed in IgG hypogammaglobulinaemia.

About the authors

N. G. Chernova

National Research Center for Hematology

Author for correspondence.
Email: ngchernova@mail.ru
Russian Federation

D. S. Tihomirov

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

N. P. Soboleva

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

S. A. Mariina

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

Y. V. Sidorova

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

M. N. Sinitsyna

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

V. N. Dvirnyk

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

S. M. Kulikov

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

T. A. Tupoleva

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

E. E. Zvonkov

National Research Center for Hematology

Email: noemail@neicon.ru
Russian Federation

References

  1. Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., et.al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2008.
  2. de Leval L., Gisselbrecht C., Gaulard P. Advances in the understanding and management of angioimmunoblastic T-cell lymphoma. Br. J. Haematol. 2010; 148(5): 673-89.
  3. Чернова Н.Г., Виноградова Ю.Е., Сидорова Ю.В., Капланская И.Б., Гилязитдинова Е.А., Горенкова Л.Г. и др. Длительные режимы цитостатической терапии ангиоиммунобластной Т-клеточной лимфомы. Клиническая онкогематология. Фундаментальные исследования и клиническая практика. 2014; 7(1): 57-62
  4. Lin P., Hao S., Handy B.C., Bueso-Ramos C.E., Medeiros L.J. Lymphoid neoplasms associated with IgM paraprotein: a study of 382 patients. Am. J. Clin. Pathol. 2005; 123(2): 200-5
  5. Чернова Н.Г., Виноградова Ю.Е., Марьина С.А., Двирнык В.Н., Сидорова Ю.В., Синицына М.Н. и др. Значение иммунохимического исследования при ангиоиммунобластной Т-клеточной лимфоме. Гематология и трансфузиология. 2016; 61(Прил. 1): 192
  6. Weiss L.M., Jaffe E.S., Liu X.F., Chen Y.Y., Shibata D., Medeiros L.J. Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Blood. 1992; 79(7): 1789-95.
  7. Knecht H., Sahli R., Shaw P., Meyer C., Bachmann E., Odermatt B.F., et.al. Detection of Epstein-Barr virus DNA by polymerase chain reaction in lymph node biopsies from patients with angioimmunoblastic lymphadenopathy. Br. J. Haematol. 1990; 75(4): 610-4.
  8. Kim H.J., Ko Y.H., Kim J.E., Lee S.S., Lee H., Park G., et.al. Epstein-Barr Virus-Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification. J. Pathol. Transl. Med. 2017; 51(4): 352-358.
  9. Longnecker R.M., Kieff E., Cohen J.I. Epstein-Barr Virus. In: Knipe D.M., Howley P.M., Griffin D.E., Lamb R.A., Martin M.A., Roizman B., eds. Fields Virology. Chapter 61. Volume 2. Philadelphia: Lippincott Williams Wilkins; 2013: 1898-959.
  10. Anagnostopoulos I., Hummel M., Finn T., Tiemann M., Korbjuhn P., Dimmler C., et.al. Heterogeneous Epstein-Barr virus infection patterns in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. Blood. 1992; 80(7): 1804-12.
  11. Dogan A., Attygalle A.D., Kyriakou C. Angioimmunoblastic T-cell lymphoma. Br. J. Haematol. 2003; 121(5): 681-91.
  12. Coleman C.B., Wohlford E.M., Smith N.A., King C.A., Ritchie J.A., Baresel P.C., et.al. Epstein-Barr virus type 2 latently infects T cells, inducing an atypical activation characterized by expression of lymphotactic cytokines. J. Virol. 2015; 89(4): 2301-12.
  13. Gru A.A., Haverkos B.H., Freud A.G., Hastings J., Nowacki N.B., Barrionuevo C., et.al. The Epstein-Barr Virus (EBV) in T Cell and NK Cell Lymphomas: Time for a Reassessment. Curr. Hematol. Malig. Rep. 2015; 10(4): 456-67.
  14. Xu Y., McKenna R.W., Hoang M.P., Collins R.H., Kroft S.H. Composite angioimmunoblastic T-cell lymphoma and diffuse large B cell lymphoma: a case report and review of the literature. Am. J. Clin. Pathol. 2002; 118(6): 848-54.
  15. Luppi M., Marasca R., Barozzi P., Artusi T., Torelli G. Frequent detection of human herpesvirus-6 sequences by polymerase chain reaction in paraffin-embedded lymph nodes from patients with angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Leuk Res. 1993; 17(11): 1003-11.
  16. Kondo К., Kazuhiro T., Okuno T., Takahashi M., Yamanashi K. Latent human herpesvirus 6 infection of human monocytes/macrophages. J. Gen. Virol. 1991; 72(6): 1401-8.
  17. Ковынев И.Б., Агеева Т.А, Обгольц Ю.Н. Клинические маски периферических Т-клеточных лимфом: ангиоиммунобластная Т-клеточная неходжкинская лимфома. Сибирский научный медицинский журнал. 2011; 31(2): 108-11
  18. SAS Institute Inc. SAS 9.1. 3 Help and Documentation. 2004; Cary, NC: SAS Institute Inc.
  19. Paul J.R., Bunnell W.W. The presence of heterophile antibodies in ihfectious mononucleosis. Amer. J. Med. Sci. 1932; 183(1): 90-103.
  20. Roizman B., Knipe D.M., Whitley R.J. Herpes Simplex Viruses. In: Knipe D., Howley P., eds. Fields Virology. 5th ed. Philadelphia: Lippincott, Williams & Wilkins; 2007: 2502-601.
  21. Тихомиров Д.С., Гаранжа Т.А., Туполева Т.А., Троицкая В.В., Галстян Г.М., Филатов Ф.П. Факторы, влияющие на частоту возникновения вирусных пневмоний у онкогематологических больных. Гематология и трансфузиология. 2016; 61(1): 37-42
  22. Guerrero M.D., Swenson K.K. Herpes simplex virus-related oral mucositis in patients with lymphoma. Oncol. Nurs. Forum. 2014; 41(3): 327-30.
  23. Moldovan B., Mentha G., Majno P., Berney T., Morard I., Giostra E., et.al. Demographics and outcomes of severe herpes simplex virus hepatitis: a registry-based study. J. Hepatol. 2011; 55(6): 1222-6.
  24. Гурцевич В.Э. Роль вируса Эпштейна-Барр в онкогематологических заболеваниях человека. Клиническая онкогематология. Фундаментальные исследования и клиническая практика. 2010; 3(3): 222-34
  25. Tempera I., Lieberman P.M. Epigenetic regulation of EBV persistence and oncogenesis. Semin. Cancer Biol. 2014; 26: 22-9

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Chernova N.G., Tihomirov D.S., Soboleva N.P., Mariina S.A., Sidorova Y.V., Sinitsyna M.N., Dvirnyk V.N., Kulikov S.M., Tupoleva T.A., Zvonkov E.E.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-77676 от 29.01.2020.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies