Методы диагностики прионных заболеваний


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Эпидемия губкообразной энцефалопатии крупного рогатого скота в Великобритании и связанное с ней возникновение среди людей нового варианта болезни Крейтцфельда-Якоба (нвБКЯ), а также доказанные случаи заражения пациентов нвБКЯ путем переливания крови инициировали интенсивные исследования в области создания недорогого, быстрого и чувствительного метода ранней прижизненной диагностики прионных заболеваний. Это позволило бы начать своевременное лечение пациентов и предотвратить попадание контаминированных продуктов в пищевую цепь. Однако, несмотря на значительный прогресс, достигнутый в этом направлении, поставленная задача полностью не была решена. В настоящем обзоре представлены существующая на сегодняшний день информация о методах диагностики трансмиссивных губкообразных энцефалопатий, а также последние разработки в области ультрачувствительной детекции этих заболеваний, основанной на изменении конформации белка приона.

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