Problems of VirologyProblems of Virology0507-40882411-2097Central Research Institute for Epidemiology60310.36233/0507-4088-110Review ArticleEnteral viral hepatitis in monkeysDogadovDmitriy I.<p>Ph.D. (Biol.), Researcher of the Laboratory of Infection Virology</p>dima_loko86@mail.ruhttps://orcid.org/0000-0003-1596-0509KyuregyanKaren K.<p>D.Sci. (Biol.), Professor of the RAS, Leading Researcher of the Laboratory of Viral Hepatitis, Head of the Department of Viral Hepatitis of the Research Institute of Molecular and Personalized Medicine</p>karen-kyuregyan@yandex.ruhttps://orcid.org/0000-0002-3599-117XMikhailovMikhail I.<p>Ph.D. (Biol.), Professor, Academician of RAS, Head of the Laboratory of Viral Hepatitis, Science Head of the Research Institute of Molecular and Personalized Medicine</p>michmich2@yandex.ruhttps://orcid.org/0000-0002-6636-6801FSBRI «Research Institute of Medical Primatology» of the Ministry of Education and Science of RussiaFSBRI «I.I. Mechnikov Research Institute of Vaccines and Sera»FSBEI FPE «Russian Medical Academy of Continuous Professional Education» of the Ministry of Health of Russia0509202267317318413042022Copyright © 2022, Dogadov D.I., Kyuregyan K.K., Mikhailov M.I.2022<p>Within the last decade, a large number of viruses genetically related to human hepatitis viruses have been identified in different animal species, including monkeys. Numerous viruses related to human hepatitis A virus (HAV, Picornaviridae: Hepatovirus: Hepatovirus A) were detected in various mammalian species in 20152018, predominantly in bats and rodents, but also in shrews, seals and marsupials. Zoonotic hepatitis E virus (HEV, Hepeviridae: Orthohepevirus: Orthohepevirus A) genotypes have been found in wild boars, deer, camels, and rabbits, as well as in non human primates. In addition, viruses that are genetically close to HEV have been described in bats, ferrets, rodents, birds, and fish. Nevertheless, monkeys remain important laboratory animals in HAV and HEV research. The study of spontaneous and experimental infection in these animals is an invaluable source of information about the biology and pathogenesis of these viruses and continues to be an indispensable tool for vaccine and drug testing. The purpose of this literature review was to summarize and analyze published data on the circulation of HAV and HEV among wild and captive primates, as well as the results of experimental studies of HAV and HEV infections in monkeys.</p>hepatitis A virus (HAV)hepatitis E virus (HEV)monkeysвирус гепатита А (ВГА)вирус гепатита Е (ВГЕ)обезьяны[Drexler J.F., Corman V.M., Lukashev A.N., van den Brand J.M.A., Gmyl A.P., Brünink S., et al. The Hepatovirus Ecology Consortium. Evolutionary origins of hepatitis A virus in small mammals. PNAS. 2015; 112(49): 15190–5. https://doi.org/10.1073/pnas.1516992112][Sridhar S., Teng J.L.L., Chiu T.H., Lau S.K.P., Woo P.C.Y. 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