Problems of VirologyProblems of VirologyВопросы вирусологии0507-40882411-2097Central Research Institute for Epidemiology359REVIEWSОБЗОРЫNew approaches to the treatment of the flavivirus infectionsНовые подходы к лечению флавивирусных инфекцийMorozovaO. V.МорозоваО. В.
Russian Federation

Olga Morozova, MD,PhD, ScD

123098, Moscow

Морозова Ольга Владимировна, д-р биол. наук, вед. науч. сотр.

123098, г. Москва

omorozova2010@gmail.comIsaevaE. I.ИсаеваЕ. И.
Russian Federation

123098, Moscow

123098, г. Москва

ViazovS. O.ВязовС. О.
Germany

Essen

Эссен

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian FederationИнститут вирусологии им. Д.И. Ивановского ФГБУ «Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи» Минздрава РоссииVirology Institute of University HospitalИнститут вирусологии, госпиталь Университета Дуйсбург-Эссен28122015606591107202011072020Copyright ©; 2015, Morozova O.V., Isaeva E.I., Viazov S.O.Copyright ©; 2015, Морозова О.В., Исаева Е.И., Вязов С.О.2015Morozova O.V., Isaeva E.I., Viazov S.O.Морозова О.В., Исаева Е.И., Вязов С.О.https://creativecommons.org/licenses/by/4.0https://virusjour.crie.ru/jour/article/view/359

Since spontaneous mutagenesis and quasi-species rearrangements of the ma-containing viruses, as well as an absence of both viral and cellular RNA reparation systems, causes resistance to originally effective antiviral drugs, combination therapy with nucleoside and non-nucleoside inhibitors of the viral enzymes in combination with immunomodulators is recommended. The use of specific immunoglobulins does not result in complete elimination of the flaviviruses but rather in possible antibody-dependent enhancement of the flavivirus infection by means of increased penetration of complexes of virions with specific antibodies into cells with receptors for Fc-fragments of immunoglobulins.

Поскольку спонтанный мутагенез и быстрые перестройки квазивидов РНК-содержащих флавивирусов, а также отсутствие вирусных и клеточных систем репарации РНК приводят к устойчивости к индивидуальным изначально эффективным противовирусным препаратам, рекомендуют комбинированную терапию нуклеозидными и ненуклеозидными ингибиторами вирусных ферментов в сочетании с иммуномодуляторами. Применение специфических иммуноглобулинов не только не обеспечивает полной элиминации большинства флавивирусов, но может приводить к усилению их инфекционности вследствие проникновения комплексов вирионов со специфичными антителами в клетки с рецепторами для Fс-фрагментов иммуноглобулинов.

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