Problems of VirologyProblems of VirologyВопросы вирусологии0507-40882411-2097Central Research Institute for Epidemiology11910ArticlesСтатьиDrug resistance of HIV-1 as a result of using nevirapine for chemoprophylaxis of vertical viral transmission from HIV-infected mother to infantЛекарственная устойчивость ВИЧ-1 как результат примененияневирапина для химиопрофилактики вертикальной передачи вируса от ВИЧ-инфицированной матери ребенку15022009541NO1 (2009)№1 (2009)09062023Copyright ©; 2009, Kazennova E.V., Kazennova E.V.Copyright ©; 2009, Казеннова Е.В., Kazennova E.V.2009Kazennova E.V., Kazennova E.V.Казеннова Е.В., Kazennova E.V.https://creativecommons.org/licenses/by/4.0https://virusjour.crie.ru/jour/article/view/11910

The review presents data on the use of a single prophylactic dose of nevirapine at labor given to a mother at the onset of labor in HIV-infected women and neonatal infants within 72 hours after birth in the absence of chemoprophylaxis with antiviral agents during pregnancy. The administration of nevirapine is shown to result in the occurrence of resistance mutations, most of which can be identified only if superfine methods are applied. Whether nevirapine may be used for chemoprophylaxis of the vertical transmission of the virus in Russia is discussed.

В обзоре представлены данные по применению однократной профилактической дозы невирапина при родах для ВИЧ-инфицированных женщин и новорожденных в течение 72 ч после рождения в отсутствие химиопрофилактики противовирусными препаратами в период беременности. Показано, что использование невирапина приводит к возникновению мутаций резистентности, большинство из которых можно идентифицировать лишь с применением супертонких методов. Обсуждается возможность применения невирапина для химиопрофилактики вертикальной передачи вируса в России.

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