Problems of VirologyProblems of VirologyВопросы вирусологии0507-40882411-2097Central Research Institute for Epidemiology11860ArticlesСтатьиSpectrumof cytokines produced by blood leukocytes in infection of herpes simplex virus, type 1Спектр цитокинов, продуцируемых лейкоцитами кровипри инфекции вирусом простого герпеса типа 115082004494NO4 (2004)№4 (2004)394309062023Copyright ©; 2004, Shcheglovitova O.N., Maxyanina E.V.Copyright ©; 2004, Щегловитова О.И., Максянина Е.В.2004Shcheglovitova O.N., Maxyanina E.V.Щегловитова О.И., Максянина Е.В.https://creativecommons.org/licenses/by/4.0https://virusjour.crie.ru/jour/article/view/11860

Three types of reaction of human blood leucocytes to herpes simplex virus 1 (HSV-1) were detected. The first reaction type, i.e. production of IFN-a, IFN-y, IL-1(J, IL-6 and TNFa but not of IL-2 or lL-4, denotes the primary body reaction to an infectious agent. The second reaction type is related with infection of activated HSV-1 leucocytes and is accompanied by an inhibited production of IFN-y, IL-6 and IL-8, which is targeted at suppressing the antivirus cell mechanisms. The third reaction type is associated with production of IFN-a, IFN-y, IL-p, IL-6 and TNFa by blood leucocytes affected by HSV-1-infected leucocytes.

Выявлено 3 типа реакции лейкоцитов крови человека на вирус простого герпеса типа 1 (ВПГ-1). Первый тип реакции - продукция ИФН-а, ИФН-у, ИЛ-10, ИЛ-6, ФНОа, но не ИЛ-2 и ИЛ-4 отражает первичную защитную реакцию организма на попадание инфекционного агента. Второй тип реакции связан с инфекцией активированных лейкоцитов ВПГ-1 и сопровождается ингибицией продукции ИФН-у, ИЛ-6 и ИЛ-8, направленной на подавление антивирусных клеточных механизмов. Третий тип реакции связан с продукцией лейкоцитами крови ИФН-а, ИФН-7, ИЛ-1р, ИЛ-6 и ФНОа под влиянием инфицированных ВПГ-1 лейкоцитов.

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